|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Studies examining the relationship of somatic PTEN status and follicular thyroid neoplasms have only demonstrated a variable subset of tumors that have somatic monoallelic deletions of PTEN, suggesting that other tumor suppressor genes may be present in this region.
|
10534767 |
1999 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
PTEN knockdown in thyroid cancer cell lines stabilized intracellular NIS protein by promoting an interaction with NIS-LARG (leukemia-associated RhoA guanine exchange factor).
|
30217930 |
2018 |
|
Thyroid Neoplasm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our study shows that low blood PTEN protein expression could serve as a screening molecular correlate to predict for germline PTEN mutation in CS and CS-like presentations of thyroid cancer.
|
23066114 |
2012 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels.
|
30086162 |
2018 |
|
Thyroid Neoplasm
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
The authors found an interesting association of PTEN methylation with the activating genetic alterations in the PI3K/AKT pathway in thyroid tumors.
|
18831514 |
2008 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.
|
9140396 |
1997 |
|
Thyroid Neoplasm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To approach further the frequency and mechanism behind PTEN silencing, we screened a panel of 87 sporadic thyroid tumors for PTEN mRNA expression, including 14 anaplastic carcinomas, 37 follicular carcinomas, 21 atypical adenomas, and 15 ordinary adenomas.
|
12203792 |
2002 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent novel and promising findings include additional abnormalities in key pathways associated with thyroid tumorigenesis (RET-Ras-BRAF-MEK; RET-beta-cateinin; TRK-PI3K-AKT; and MDM-p53-PTEN), single-nucleotide polymorphisms associated with thyroid cancer susceptibility, epigenetic silencing, alternative splicing, and gene expression abnormalities.
|
19907326 |
2010 |
|
Thyroid Neoplasm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we demonstrate that PTEN may act as a suppressor of thyroid cancerogenesis as the constitutive re-expression of PTEN into two different thyroid tumor cell lines markedly inhibits cell growth.
|
10918569 |
2000 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The transcriptional silencing of PTEN was significantly associated with the anaplastic subtype, suggesting that PTEN is involved in the carcinogenesis of highly malignant or late-stage thyroid cancers, whereas this particular mechanism appears to be of minor importance in differentiated follicular thyroid tumors.
|
12203792 |
2002 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Mutations in BRAF, NRAS, KRAS and PTEN, that are known to be involved in thyroid cancer biology, were detected in seven FNA samples.
|
24834793 |
2015 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PTEN/MMAC1 was also identified as the gene predisposing to Cowden disease, an autosomal dominant cancer predisposition syndrome associated with an increased risk of breast, skin and thyroid tumors and occasional cases of other cancers including bladder and renal cell carcinoma.
|
9671402 |
1998 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
PTEN, a dual-phosphatase tumor suppressor, is inactivated in Cowden syndrome (CS), characterized by high risk of breast and thyroid cancer, and in variety of sporadic cancers.
|
16436456 |
2006 |
|
Thyroid Neoplasm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our data define a novel mechanism of PI3K/AKT hyperactivation and outline a regulatory role for miR-146b in suppressing PTEN expression, a frequent observation in thyroid cancer.
|
29353884 |
2018 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Germ-line PTEN mutations were detected in all of five families with both breast cancer and CD, in one family with juvenile polyposis syndrome, and in one of four families with breast and thyroid tumors.
|
9399897 |
1997 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
At the present time, no study has been undertaken to consider thyroid cancer treatment via FOXOs and PTEN targeting.
|
26597586 |
2016 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interestingly, KLLN-associated risk of thyroid cancer appears to be gender and PTEN status dependent.
|
25669429 |
2015 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
LHGDN |
ATP modulates PTEN subcellular localization in multiple cancer cell lines.
|
18579579 |
2008 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Because of this overlapping function with PTEN and the physical location of MINPP1 to a region with frequent LOH in follicular thyroid tumors, we considered it to be an excellent candidate gene that could contribute to the pathogenesis of follicular thyroid tumors.
|
11297621 |
2001 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations in PTEN have been described in sporadic thyroid tumors, endometrial carcinomas, prostate carcinomas and glioblastoma multiforme.
|
9472113 |
1998 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here, we demonstrated a novel germline mutation in PTEN, as well as somatic loss of the wild-type PTEN allele in breast and thyroid tumors in a patient with Cowden syndrome.
|
23295304 |
2012 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The latter could explain the clinically observed decrease in thyroid cancer prevalence in patients with co-existent PTEN mutations and SDHx variants.
|
28164237 |
2017 |
|
Thyroid Neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Overall, our results suggest that PTEN can function as an important modulator of extracellular matrix proteins in thyroid cancer.
|
15707585 |
2005 |
|
Thyroid Neoplasm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We show that SRC inhibition could rescue SDHD dysfunction-induced cellular phenotype and tumorigenesis only when wild-type PTEN is expressed, in thyroid cancer lines.
|
25149476 |
2015 |
|
Thyroid Neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Somatic PTEN mutations commonly occur in endometrial, breast, prostate, and thyroid tumors.
|
11891178 |
2002 |