Lung Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because <i>Ipo11</i> mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor.
|
28193699 |
2017 |
Lung Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
The ISG15-specific protease USP18 regulates stability of PTEN.
|
27980214 |
2017 |
Lung Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
These findings explain the correlation between loss of IPO11 and PTEN protein in human lung tumors.
|
28193700 |
2017 |
Lung Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
To investigate the effect of olaparib and cisplatin on PTEN-deficient lung tumors, two EGFR-mutant (deletion in exon19) non-small cell lung cancer (NSCLC) cell lines, PC-9 (PTEN wild-type) and H1650 (PTEN loss), were used.
|
23239809 |
2013 |
Lung Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
To explore the spectrum of driver mutations among lung cancer tissues from never smokers, specifically in a population where high lung cancer rates have been attributed to indoor air pollution from domestic coal use, multiplexed assays were used to detect >40 point mutations, insertions, and deletions (EGFR, KRAS, BRAF, HER2, NRAS, PIK3CA, MEK1, AKT1, and PTEN) among the lung tumors of confirmed never smoking females from Xuanwei, China [32 adenocarcinomas (ADCs), 7 squamous cell carcinomas (SCCs), 1 adenosquamous carcinoma (ADSC)].
|
24055406 |
2013 |
Lung Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
|
17909629 |
2007 |
Lung Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors.
|
17912443 |
2007 |
Lung Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha.
|
15802268 |
2005 |
Lung Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
To determine whether SP-A aberrations are lung cancer-specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC.
|
16061856 |
2005 |
Lung Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Mutations of this gene are common in brain, prostate, endometrial, and gastric cancers but occur rarely in non-small-cell lung cancer (NSCLC), although the PTEN protein is often lost in lung tumors.
|
16084946 |
2005 |
Lung Neoplasms
|
0.700 |
PosttranslationalModification
|
group |
LHGDN |
RRM1-induced metastasis suppression through PTEN-regulated pathways.
|
12687015 |
2003 |
Lung Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
All the lung tumors with PTEN/MMAC1/TEP1 mutations were homozygous for the mutant alleles.
|
9598803 |
1998 |
Lung Neoplasms
|
0.700 |
Biomarker
|
group |
HPO |
|
|
|
Lung Neoplasms
|
0.700 |
GenomicAlterations
|
group |
CGI |
|
|
|
Lung Neoplasms
|
0.700 |
CausalMutation
|
group |
CGI |
|
|
|