PTEN, phosphatase and tensin homolog, 5728

N. diseases: 1349; N. variants: 384
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE These findings indicated that Linc01296 is involved in HCC progression via regulating miR-26a/PTEN. 31318685 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE In this study, we aimed to investigate the biological function roles of lncRNAs growth arrest-specific 5 (GAS5) and its underlying molecular mechanism in the development of HCC. qRT-PCR was used to detect GAS5, miR-21, and PTEN levels. 31705194 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE Forced overexpression of H19 attenuated miR-193b-mediated inhibition on multiple driver oncogenes (EGFR, KRAS, PTEN and IGF1R) and MAPK1 gene, thus triggered EMT and stem cell transformation in HCC. 31705929 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation disease BEFREE Only the mutation in PTEN has a common Catalogue of Somatic Mutations in Cancer ID in the CLC and coexistent HCC-like area, and is related to the kinase-RAS module. 31261448 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE Spearman correlation analysis revealed that the expression profiles of ZHX2 and PTEN were positively correlated in HCC tissues (r=0.258, P=0.031). 30784286 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE This study aims to investigate the anticancer effect of Oroxin B (OB) both in vitro and in vivo, and the molecular mechanism involved in microRNA-221 and the PI3K/Akt/PTEN pathway through modulation of apoptosis in Hepatocellular carcinoma (HCC). 31801250 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE While AKT2 is the major isoform downstream of activated phosphoinositide 3-kinase and loss of phosphatase and tensin homolog-induced HCC, the precise function of AKT1 in hepatocarcinogenesis is largely unknown. 31062368 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE The detection of miRNAs in exosomes of HCC showed that miR-21 expression in exosomes was positively correlated with the expression level of miR-21 in cells and negatively correlated with the expression of its target genes PTEN, PTENp1 and TETs. 31656200 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE Recuse assays showed that restoration of PTEN reversed the effects of miR-3691-5p on HCC cell migration and invasion through decreasing PI3K/Akt signaling. 31417285 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE In addition, PTEN was highly expressed in HCC tissues compared with normal adjacent tissues and was positively associated with FER1L4. 30431133 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE LncRNA F11-AS1 suppresses liver hepatocellular carcinoma progression by competitively binding with miR-3146 to regulate PTEN expression. 31168823 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE Moreover, reduced TP73-AS1 was able to decline the phosphorylation of Akt and increase the expression of PTEN in HCC. 31564201 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE To investigate molecular alteration and expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene in hepatocellular carcinoma (HCC), and to evaluate the correlation between PTEN and cancer stem cell (CSC) markers and the prognostic value of these markers. 31126975 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE STAT3-induced upregulation of lncRNA CASC11 promotes the cell migration, invasion and epithelial-mesenchymal transition in hepatocellular carcinoma by epigenetically silencing PTEN and activating PI3K/AKT signaling pathway. 30503497 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE Rpn10 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through the PTEN/Akt signaling pathway in hepatocellular carcinoma. 30673593 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE <b>Background:</b> A recent study has revealed that miR-106b-5p might promote hepatocellular carcinoma (HCC) stemness maintenance and metastasis by targeting PTEN via PI3K/Akt pathway based on HCC cell lines and animal models.Its clinical relevance remains unknown. 31406464 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE Thus, our findings suggest for the first time that miR-26a promotes invasion/metastasis by inhibiting PTEN and inhibits cell proliferation by repressing EZH2 in HCC. 31201367 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE SEMA3B-AS1 in HCC tissues was inversely correlated with microRNA (miR)-718 and positively correlated with PTEN. 31251699 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE Mechanistically, circHIAT1 acted as the miR-3171 sponge to upregulate PTEN in HCC. 31108351 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE Here we show that methyltransferase-like 1 (METTL1) is upregulated in hepatocellular carcinoma (HCC) and exhibits oncogenic activities via PTEN/AKT signaling pathway. 31463732 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE We conclude that miR-128-3p overexpression sensitized HCC to sorafenib-induced apoptosis via PTEN/PI3K/Akt signaling pathway by regulating DJ-1 expression. 30402839 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE Down-regulation of LncRNA NR027113 inhibits cell proliferation and metastasis via PTEN/PI3K/AKT signaling pathway in hepatocellular carcinoma. 30468465 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE MiR-328 is involved in the development of HCC via regulating PTEN, which might provide a new target for HCC diagnosis and therapy. 30338800 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression disease BEFREE High-expressed CKS2 is associated with hepatocellular carcinoma cell proliferation through down-regulating PTEN. 29487004 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker disease BEFREE Aberrant expression of miR-19a-3p stimulated HCC cell metastasis, and phosphatase and tensin homolog (PTEN) was shown to be a direct target of miR-19a-3p. miR-19a-3p-mediated HCC metastasis was reversed by restoration of PTEN or could be imitated by silencing of PTEN. 30021351 2018