|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
EP1 receptor is involved in prostaglandin E2-induced osteosarcoma growth.
|
30995899 |
2019 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
EP1 receptor is involved in prostaglandin E2-induced osteosarcoma growth.
|
30995899 |
2019 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
EP1 receptor is involved in prostaglandin E2-induced osteosarcoma growth.
|
30995899 |
2019 |
|
Conn Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An integration study between microarray and methylation analysis revealed that HTR4, MC2R, TACR1, GRM3, and PTGER1 showed hypo-methylation and up-regulation of mRNA in APA. qPCR analysis showed that HTR4 and PTGER1 expression was 9.3-fold and 6.6-fold higher in APAs than in NFAs, respectively, whereas expression of the other genes was not different between the groups.
|
28870781 |
2018 |
|
Heartburn
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
ONO-8539 attenuated acid-induced heartburn in healthy male subjects, suggesting that EP1 receptors play a role in generation of heartburn symptoms.
|
28120127 |
2017 |
|
Urticaria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.
|
26959713 |
2016 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our studies indicate that inhibition of COX-2 can arrest prostate cancer cell cycle progression through inactivation of the EP1 receptor signaling and down-regulation of kinetochore/centromere proteins.
|
24802614 |
2014 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our studies indicate that inhibition of COX-2 can arrest prostate cancer cell cycle progression through inactivation of the EP1 receptor signaling and down-regulation of kinetochore/centromere proteins.
|
24802614 |
2014 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that PGE2-enhanced MMP2 expression is, at least in part, mediated through EP1 receptors and calcium signaling pathway-induced CREB phosphorylation in human cholangiocarcinoma cells.
|
23494562 |
2013 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exploring potential therapeutic agent targeting EP1 receptor could potentially benefit treatments for stroke and AD patients.
|
22015313 |
2012 |
|
Amnesia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic deletion of the prostaglandin EP1 receptor significantly attenuated the more severe neuronal damage (38.5 ± 10.6%) and memory loss induced by ischemic insult observed in AD transgenic mice (percentage of viable hippocampal CA1 neurons: 11.2 ± 2.9%) when compared with wild type mice (45.1 ± 9.1%).
|
22015313 |
2012 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study was designed to delineate the prostaglandin E(2) EP1 receptor role in AD and in the setting of cerebral ischemia.
|
22015313 |
2012 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Exploring potential therapeutic agent targeting EP1 receptor could potentially benefit treatments for stroke and AD patients.
|
22015313 |
2012 |
|
Memory Loss
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Genetic deletion of the prostaglandin EP1 receptor significantly attenuated the more severe neuronal damage (38.5 ± 10.6%) and memory loss induced by ischemic insult observed in AD transgenic mice (percentage of viable hippocampal CA1 neurons: 11.2 ± 2.9%) when compared with wild type mice (45.1 ± 9.1%).
|
22015313 |
2012 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here we investigated (a) the expression profile of the PGE synthase enzymes (PTGES, PTGES-2, PTGES-3) and PGE receptors (PTGER1-4) in endometrial adenocarcinomas compared with normal endometrium and (b) the role of PTGER4 in endometrial tumorigenesis in vivo.
|
21589857 |
2011 |
|
Chondrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we found that human chondrosarcoma tissues expressed a higher level of EP1 receptor than normal cartilage.
|
20178602 |
2010 |
|
Impulsive aggression
|
0.010 |
Biomarker
|
disease |
BEFREE |
As Ptger1-null mice show behavioral inhibition and impulsive aggression with defective social interaction, PTGER1 haploinsufficiency may be responsible for the behavioral traits observed in these patients.
|
20648052 |
2010 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, no association was found between any genetic variation in Ptger1, Ptger2, or Ptger4 and asthma.
|
17877755 |
2007 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Specific components of prostanoid-signaling pathways are present in non-small cell lung cancer cells.
|
17611676 |
2007 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of COX-2 in cultured HCC cells (Hep3B) or treatment with PGE(2) or the selective EP(1) receptor agonist, ONO-DI-004, increased EGFR phosphorylation and tumor cell invasion.
|
16331686 |
2006 |
|
Hypertensive disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In the present study, we focus on DNA methylation profiles of prostaglandin E receptor 1 gene (<i>ptger1</i>), which is known to be associated with hypertension.
|
30301128 |
2018 |
|
Hypertensive disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Disruption of the EP1 receptor in C57BL/6J mice reduced the incidence of mortality during severe hypertension induced by uninephrectomy, deoxycorticosterone acetate, and angiotensin II.
|
23006735 |
2012 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The present study investigated the effect of EP1 receptor activation on β1-integrin expression and cell migration in HCC.
|
25289898 |
2014 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our study suggests that the PGE₂ EP1 receptor regulates FAK phosphorylation by activating the PKC/c-Src and EGFR signal pathways, which may coordinately regulate adhesion and migration in HCC.
|
23525457 |
2013 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
PGE(2) regulates survivin expression in hepatocellular carcinoma cells through the EP1 receptor by activating the EGFR/PI3K pathway.
|
20035770 |
2010 |