AICDA, activation induced cytidine deaminase, 57379

N. diseases: 265; N. variants: 16
Disease: Leukemogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis. 29335468 2018
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Numerous studies have shown that AID preferentially targets Ig substrates and also attacks non-Ig substrates to create DNA damage that contributes to lymphomagenesis. 26845615 2016
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE We found that CLT and AID-deficient CLT ES chimeras had indistinguishable phenotypes, showing that AID is not essential for LMP1-induced lymphomagenesis. 25934172 2015
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Importantly, AID triggers the adaptive immune response involving error-prone processing of U:G mismatches, but also contributes to B-cell lymphomagenesis. 24746924 2014
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 AlteredExpression disease BEFREE A plausible mechanism by which infection might impact the process of leukemogenesis via genetic alteration is through: oxidative stress/DNA damage which is closely linked with inflammation, aberrant expression of AID/ABOBEC family enzymes which may be responsible for massive mutation introduction and alteration of DNA methylation, leading to changes in the expression of hematopoietic genes. 25003587 2014
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 AlteredExpression disease BEFREE Here, we report an intracellular mechanism by which LMP1 contributes to B cell lymphomagenesis via AID expression. 23363221 2013
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Here, we review the molecular basis of AID regulation, targeting, and initiation of CSR and SHM, as well as AID's role in generating chromosome translocations that contribute to lymphomagenesis. 22429855 2012
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Emerging evidence supports a key role of AID in lymphomagenesis through genome-wide off-target induction of point mutations and chromosome translocations. 22517589 2012
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 AlteredExpression disease BEFREE As a bystander effect, endogenous AID levels can also promote the generation of chromosome translocations, suggesting that the fine tuning of AID expression may be critical to restrict B cell lymphomagenesis. 18762567 2008
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 AlteredExpression disease BEFREE These findings indicate that EBV induced AID and pol-eta expression, and that this was associated with oncogene mutation, providing a novel means by which EBV infection of B cells may contribute to lymphomagenesis. 16730063 2007
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 AlteredExpression disease BEFREE Here, we review the most recent findings on the regulation of AID targeting and discuss how AID activity on non-Ig genes is relevant to the generation of chromosome translocations and to lymphomagenesis. 16861038 2006
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 AlteredExpression disease BEFREE These results indicate that the AID protein is specifically expressed in normal and transformed GC B cells; nonetheless, its predominantly cytoplasmic localization suggests that additional mechanisms may regulate its function and may be altered during lymphomagenesis. 15304391 2004