|
Schizophrenia
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
We found that levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased, and levels of prostaglandin-endoperoxide synthase 2 (PTGS2; aka COX-2) mRNA are decreased, in older subjects with schizophrenia (> 40years of age) compared to matched normal controls or younger subjects with schizophrenia (< 40years of age).
|
22397921 |
2012 |
|
Schizophrenia
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia.
|
15041036 |
2004 |
|
Schizophrenia
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population.
|
15519500 |
2004 |
|
Schizophrenia
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
Eight SNPs detected across the PPARG gene did not show allelic association with schizophrenia; a weak association was detected at rs2745557 in the PTGS2 locus (chi2=4.19, p=0.041) and rs10798059 in the PLA2G4A locus (chi2=4.28, p=0.039) but these associations did not survive after 10,000 permutations to correct the p-value (global p=0.246).
|
19560328 |
2009 |
|
Schizophrenia
|
0.550 |
AlteredExpression
|
disease |
LHGDN |
These results suggest that celecoxib may affect the pathophysiology of schizophrenia through COX-2-independent actions rather than by inhibiting activity of up-regulated COX-2 protein.
|
15276698 |
2004 |
|
Schizophrenia
|
0.550 |
GeneticVariation
|
disease |
LHGDN |
The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia.
|
15041036 |
2004 |
|
Schizophrenia
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.
|
15519500 |
2004 |
|
Schizophrenia
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Eight SNPs detected across the PPARG gene did not show allelic association with schizophrenia; a weak association was detected at rs2745557 in the PTGS2 locus (chi2=4.19, p=0.041) and rs10798059 in the PLA2G4A locus (chi2=4.28, p=0.039) but these associations did not survive after 10,000 permutations to correct the p-value (global p=0.246).
|
19560328 |
2009 |
|
Schizophrenia
|
0.550 |
Biomarker
|
disease |
PSYGENET |
We found that levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased, and levels of prostaglandin-endoperoxide synthase 2 (PTGS2; aka COX-2) mRNA are decreased, in older subjects with schizophrenia (> 40years of age) compared to matched normal controls or younger subjects with schizophrenia (< 40years of age).
|
22397921 |
2012 |
|
Schizophrenia
|
0.550 |
Biomarker
|
disease |
PSYGENET |
The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia.
|
15041036 |
2004 |
|
Schizophrenia
|
0.550 |
Biomarker
|
disease |
RGD |
A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor.
|
17881518 |
2007 |