|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that PHS-2 is transcribed abnormally in human colon cancers and that this may be one mechanism by which prostaglandins or related compounds that support carcinogenesis are generated.
|
8643486 |
1996 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results suggest that cyclooxygenase-2 is involved in the increased prostaglandin E2 synthesis in colonic cancers, and that activation of this isoenzyme is an early event in colon carcinogenesis.
|
8566864 |
1996 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Studies with the Min and APC-knockout mice provide the strongest evidence to date that the enzyme cyclooxygenase-2 plays a major role in colon carcinogenesis, and that nonsteroidal anti-inflammatory drugs that target cyclooxygenase-2 have great potential as colon cancer chemopreventive agents.
|
9327228 |
1997 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we selected two transformed human colon cancer cell lines for studies on the role of COX-2 in intestinal tumorigenesis.
|
9151799 |
1997 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Relative to aspirin, APHS was 60 times as reactive against COX-2 and 100 times as selective for its inhibition; it also inhibited COX-2 in cultured macrophages and colon cancer cells and in the rat air pouch in vivo.
|
9596581 |
1998 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
COX-2 and colon cancer.
|
9831333 |
1998 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nonsteroidal anti-inflammatory drugs reduce the risk of colon cancer and this effect is mediated in part through inhibition of type 2 prostaglandin endoperoxide synthase/ cyclo-oxygenase (COX-2).
|
11114729 |
2000 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that flufenamic acid shows two opposing effects on COX-2 expression; it induces COX-2 expression in the colon cancer cell line (HT-29) and macrophage cell line (RAW 264.7); conversely, it inhibits tumor necrosis factor alpha (TNFalpha)- or lipopolysaccharide (LPS)-induced COX-2 expression.
|
10866999 |
2000 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
COX-2 expression was not detected in several poorly differentiated colon cancer cell lines including DLD-1.
|
10930401 |
2000 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To understand the molecular nature of enhanced COX-2 expression detected in colon cancer, we examined the ability of the AU-rich element-containing (ARE-containing) 3' untranslated region (3'UTR) of COX-2 mRNA to regulate rapid mRNA decay in human colon cancer cells.
|
11733561 |
2001 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Numerous studies have demonstrated that prostaglandin H synthase-2 (PHS-2) is involved in gastrointestinal carcinogenesis, and that nonsteroidal anti-inflammatory drugs (NSAIDs), which inhibit PHS, can reduce the risk of colon cancer.
|
11563634 |
2001 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclooxygenase-2 (COX-2), which catalyzes the rate-limiting step in the synthesis of prostaglandins from arachidonic acids, is known to be up-regulated in colon cancer, and multiple lines of evidence indicate that it is a critical early step in colon carcinogenesis.
|
11731423 |
2001 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It inhibited COX-2 expression induced by angiogenic factors and endothelial tube formation induced by angiogenic factors and colon cancer cell medium.
|
12060668 |
2002 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Results of several studies using mouse models of colon cancer and the results of clinical trials have shown COX-2 to be a useful target for the prevention and treatment of colon cancer.
|
12472107 |
2002 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prostaglandin H synthase 2 (also known as cyclooxygenase-2) is thought to play a role in the prevention of colon cancer by aspirin, an inhibitor of the enzyme.
|
12433707 |
2002 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
|
12189188 |
2002 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
COX-2 selective inhibitors can be the core drugs for the prevention and the treatment of colon cancer.
|
12432918 |
2002 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, effects of sodium butyrate on the promoter-dependent transcriptional activity of iNOS and COX-2 genes were investigated in a colon cancer cell line, DLD-1, using a reporter gene assay system.
|
11825662 |
2002 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Down-regulation of Bcl2 expression might represent a potential mechanism by which ASA induces apoptosis in this COX-2 negative colon cancer cell line.
|
12423325 |
2002 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The mechanisms regulating COX-2 expression in human colon cancer have not been completely elucidated.
|
12839952 |
2003 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
This indicates that NF-kappaB activated by NS-398 is transcriptionally inactive and is an encouraging result for the use of COX-2-selective NSAIDs not only in chemoprevention but also as novel therapies for colon cancer.
|
14520472 |
2003 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, SW480, a COX-2-negative colon cancer cell line, was treated with various concentrations of ASA (0, 2.5, 5, and 10 mM).
|
12832097 |
2003 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It is known that nitric oxide activates the cyclooxygenase 2 enzyme, which plays a pivotal role in the progression of colon cancer via prostaglandin synthesis and angiogenesis.
|
12615711 |
2003 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While concentration of PGE2 as well as expression of Cox-2, HGF receptor (c-Met-R), epidermal growth factor receptor (EGFR), and beta-catenin are all dramatically increased in colon cancers and implicated in their growth and invasion, the precise role of PGE2 in the latter process remains unclear.
|
12958170 |
2003 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a.
|
14675489 |
2003 |