Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms.
|
12494894 |
2003 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cyclooxygenase 2 (COX-2) is overexpressed frequently in aerodigestive tumors, especially in colorectal tumors.
|
15300574 |
2004 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
COX-2 overexpression is a frequent, but not universal event in colorectal neoplasms.
|
21158711 |
2011 |
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.
|
10945606 |
2000 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells.
|
17604853 |
2007 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors.
|
16174078 |
2005 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Aspirin use and survival after diagnosis of colorectal cancer.
|
19671906 |
2009 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
|
17151091 |
2007 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Bioactive metabolites downstream of cyclooxygenase-2 (COX-2) generated prostaglandin H(2) (PGH(2)), in particular prostaglandin E(2) (PGE(2)), are thought to play critical roles during the development of colorectal tumors.
|
19035518 |
2009 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis.
|
16474989 |
2006 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
|
16820091 |
2006 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
COX-2 expression and tumor angiogenesis in colorectal cancer.
|
15285012 |
2004 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer.
|
15102673 |
2004 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Cyclooxygenase-2 expression and angiogenesis in colorectal cancer.
|
12800231 |
2003 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention.
|
20427397 |
2010 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer.
|
12405290 |
2002 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases.
|
15248379 |
2004 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis.
|
19016757 |
2008 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms.
|
10204802 |
1999 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.
|
16818642 |
2006 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers.
|
17594159 |
2007 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer.
|
12727794 |
2003 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, the downstream prostaglandin (PG)-PG receptor pathway involved in these effects is poorly characterized.We studied the PG-pathway in gene expression databases and we found that PTGS2 (prostaglandin G/H synthase and cyclooxygenase) and PTGES (prostaglandin E synthase) are co-expressed in human colorectal tumors.
|
26498686 |
2015 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, overexpression of COX-2 was found more frequently in colorectal tumors with lymphatic invasion, regional lymph node metastasis and larger size, although without statistical significance.
|
15075004 |
2004 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.
|
10485483 |
1999 |