Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that overexpression of COX-2 may play an important role in tumor progression of gastric cancer and also support the notion that gastric cancers with and without MSI represent distinctive pathways of carcinogenesis.
|
10404093 |
1999 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Cyclooxygenase 2 (COX-2) overexpression has been described in sporadic colonic neoplasia, but its role in ulcerative colitis (UC) neoplastic progression remains unexplored.
|
10980113 |
2000 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
This study suggests that induction of proliferation and tumor progression of colon cancer cells by the IGF-II/IGF-I receptor pathway may depend on the activation of COX-2-related events.
|
11114729 |
2000 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These data suggest that COX-2 expression might regulate carcinogenesis of bile duct epithelial cells in inflammatory regions and tumor progression in this cancer.
|
11584358 |
2001 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results provide clinical evidence that COX-2 may contribute to tumor progression in human gastric adenocarcinoma.
|
11223821 |
2001 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Using the post-gastrectomy stomach as a model, the expression of COX-2 mRNA and protein has been investigated during tumour progression in the human stomach.
|
11793368 |
2002 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, both iNOS and COX-2 appear to be involved in Barrett's-associated neoplastic progression, but COX-2 inhibition is more promising as a chemopreventive strategy.
|
12060038 |
2002 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Selective COX-2 inhibitors reduce adenoma formation and cancer progression in rodent models of colorectal cancer.
|
11687954 |
2002 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Cyclooxygenase-2 (COX-2) seems to be involved at various steps in the processes of malignant transformation and tumor progression.
|
14508829 |
2003 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Higher Cox-2 expression might be associated with tumor progression and worse prognosis through EGFR signaling interaction in Stage I bronchial adenocarcinomas.
|
15246187 |
2004 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Cyclooxygenase-1 and cyclooxygenase-2 are enzymes involved in the production of prostaglandins and play a role in the regulation of tumor progression in several malignancies, including ovarian carcinomas.
|
15838264 |
2004 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We conclude that cyclooxygenase-2 is related with tumor progression and metastasis in colorectal cancer, which can be observed on protein level, and reflects chromosomal gain at the locus at 1q25.2-q25.3.
|
14719154 |
2004 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although accumulating evidence suggests the importance of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) in the pathogenesis of many cancers, the mechanism by which this enzyme and its metabolite promote cancer progression is unknown.
|
15120641 |
2004 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Although the precise mechanism or mechanisms by which these drugs affect tumor progression is not completely understood, it is likely that part of their anti-tumor effect is due to inhibition of the COX- 2 enzyme.
|
15285921 |
2004 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of cyclooxygenase-2 (COX-2) is known to be involved in gastric carcinogenesis and tumor progression, but little is known about the mechanisms responsible for the up-regulation of COX-2.
|
15501972 |
2004 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, the mechanism underlying COX-2's effect on tumor progression remains largely unknown.
|
14744769 |
2004 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma.
|
15049901 |
2004 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Cyclooxygenase-2 (COX-2) has been linked to neoplastic progression in Barrett's esophagus.
|
15231484 |
2004 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both heparanase and cyclooxygenase-2 (COX-2) are thought to play critical roles for tumor malignancy, including angiogenesis, although it is unknown about their relationship with each other in cancer progression.
|
16299228 |
2005 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The current results strongly suggest that a cooperative effect of the combined treatment on tumor progression is mediated through blocking both EGFR- and COX-2-related pathways.
|
16144930 |
2005 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These studies suggest that FVB/N is a susceptible mouse strain well suited to the study of COX-2 mediated tumor progression and may provide a tool for the identification of interacting genes and therapeutic treatments for this clinically important target.
|
15967164 |
2005 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression.
|
16101131 |
2005 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
COX-2 is frequently overexpressed in various types of cancer and plays an important role in tumor progression.
|
16908593 |
2006 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study first revealed the selective induction of Cox-2 by LPA led to FasL presentation on ovarian cancer cell surface and provide cancer cell immune privilege, and might provide important information of Cox-2 in cancer progression and Cox-2 inhibitors' application in cancer chemoprevention.
|
16376882 |
2006 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These models thus delineate the in vivo significance of 15-PGDH-mediated negative regulation of the COX-2 pathway and moreover reveal the particular importance of 15-PGDH in opposing the neoplastic progression of colonic aberrant crypt foci.
|
16880406 |
2006 |