Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These results reveal that the JB oil acted as a chemopreventive dietary agent, inhibiting cell proliferation and COX-2 expression and inducing apoptosis, resulting in a significant reduction in colon tumor formation.
|
31617778 |
2019 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Interestingly, carcinogenic exposure alone induced multiple colon tumors and increased cyclooxygenase-2 (Ptgs2) expression in Tph1KO mice.
|
31038736 |
2019 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In Apc(Min) (/+) mice, constitutive CpG methylation of the Fxrα3/4 promoter was linked to reduced (60-90%) baseline Fxr, Ibabp, and Shp and increased Cox-2 expression in apparently normal adjacent mucosa and colon tumors.
|
26609171 |
2016 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Western blots revealed overexpression of β-catenin, c-Myc, cyclin D1, inducible nitric oxide synthase and cyclooxygenase-2 in colon tumor samples.
|
21081470 |
2011 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Western blots revealed overexpression of β-catenin, c-Myc, cyclin D1, inducible nitric oxide synthase and cyclooxygenase-2 in colon tumor samples.
|
21081470 |
2011 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue.
|
21459756 |
2011 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
RGD |
Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF.
|
21268133 |
2011 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Moreover, CCL2 antagonists decreased intracolonic macrophage infiltration and COX-2 expression, attenuated neovascularization, and eventually reduced the numbers and size of colon tumors, even when given after multiple colon tumors have developed.
|
19773434 |
2009 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
This study investigated the relationship between E-cadherin and COX-2 in colon cancer cells and human colon tumors.
|
20046424 |
2009 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
We examined the functions of HuR and TTP during colon tumorigenesis and their ability to regulate cyclooxygenase (COX-2), a mediator of prostaglandin synthesis that increases in the colon tumor microenvironment.
|
19208339 |
2009 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Collectively, our data indicate that COX-2 promotes colon tumor progression, but not initiation, and it does so, in part, by activating EGFR and Akt signaling pathways.
|
18790560 |
2009 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer.
|
19088039 |
2008 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.
|
18326857 |
2008 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes.
|
17128412 |
2007 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Cyclooxygenase-2 (COX-2) is overexpressed in colon tumors.
|
17667525 |
2007 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Activation of beta-adrenoceptors and the subsequent stimulation of COX-2, PGE(2), and VEGF expression is perhaps an important mechanism in the tumorigenic action of nicotine on colon tumor growth.
|
17369603 |
2007 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Herein, we demonstrate that 15-PGDH is active in vivo as a highly potent suppressor of colon neoplasia development and acts in the colon as a required physiologic antagonist of the prostaglandin-synthesizing activity of the cyclooxygenase 2 (COX-2) oncogene.
|
16880406 |
2006 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Therefore, we examined the expression of SK1 and COX-2 in rat colon tumors induced by azoxymethane (AOM) and the relationship of these two proteins in normal and malignant intestinal epithelial cells.
|
16319132 |
2006 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility.
|
17178865 |
2006 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
To further explore how cancer cells exploit the progrowth actions of prostaglandins while suppressing the proapoptotic actions of intracellular arachidonic acid, we determined the cytoplasmic phospholipase A(2) (cPLA(2)) and COX-2 expression levels in a panel of human colon tumors by immunohistochemistry.
|
15788676 |
2005 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer.
|
16203768 |
2005 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We are interested in the mechanism of cyclooxygenase-2 (Cox-2) regulation in colon cancer cells because this knowledge could provide insight into colon carcinogenesis and suggest ways to suppress Cox-2 expression in colon tumors.
|
15713675 |
2005 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways.
|
15896711 |
2005 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia.
|
15574495 |
2004 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia.
|
15574495 |
2004 |