Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
1 L-1β, TNF-α and COX-2), increased BDNF expression and neurogenesis, restored the dysfunction of ATP production and oxidative stress in inflammation- induced depression.
|
31022424 |
2019 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that selective inhibition of COX-2 ameliorates depression-like behaviors in rat models of depression.
|
31539536 |
2019 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression.
|
28108057 |
2018 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
AD and depression are crucially linked by neuroinflammation and cyclooxygenase II (COX-2) enzyme involvement is an intriguing field of research.
|
29879605 |
2018 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression.
|
30526621 |
2018 |
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
PCNA, Ki-67 and COX-2 expression in cancer tissues of the patient group had no correlation with the existence of lumps and localized density-increased shadows (p>0.05), but were associated with manifestations of architectural distortion, calcification as well as skin and nipple depression (p<0.05).
|
28927045 |
2017 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
An imbalance in the cortical COX2-PGE2-cAMP/PKA-CREB-BDNF signalling pathway participates in the pathogenic mechanism of depression.
|
28352129 |
2017 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The potential of various anti-inflammatory approaches such as selective cyclooxygenase-2 inhibitors, inflammatory cytokine inhibitors, and indoleamine 2,3-dioxygenase inhibitors pertaining to their serotonin restoring effects is discussed as possible therapy for treatment of depression in epilepsy.
|
28038393 |
2017 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression.
|
22580182 |
2013 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression.
|
22580182 |
2013 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis.
|
21655952 |
2012 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis.
|
21655952 |
2012 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder.
|
22331023 |
2012 |
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes.
|
20588070 |
2010 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Genetic variations in the COX2 and PLA2 genes increase the risk of IFN-alpha-induced depression, possibly by affecting the levels of EPA and DHA.
|
20034614 |
2010 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Participants with the PLA2 BanI GG or the COX2 rs4648308 AG genotypes had a higher risk of IFN-alpha-induced depression (odds ratio = 3.1 and 3.5, respectively).
|
20034614 |
2010 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes.
|
20588070 |
2010 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Furthermore, these data indicate that chronic celecoxib treatment reverse chronic unpredictable stress-induced depressive-like behavior might via reducing COX-2 enzyme in brain, and the selective COX-2 inhibitors could be developed as potential remedies for the management of depression.
|
19356723 |
2009 |
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
COX-2 overexpression was observed in 12 of 77 (15.6%) DP and there was no significant difference between DPdep (3 of 23, 13.0%) and DPpo (9 of 54, 16.7%).
|
12397273 |
2002 |