Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we identified ursolic acid (UA) as a natural inhibitor of COX-2 and investigated its effects on endometriosis progression.
|
31527378 |
2020 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our data identify differentially expressed proteins S100A9 and S100A8, and suggest they may serve as novel molecular markers to predict postoperative recurrence of an ovarian endometriotic cysts.<b>Abbreviations:</b> iTRAQ: isobaric tags for relative and absolute quantitation; HPRD: Human Protein Reference Database; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; EM: Endometriosis; COX-2: cyclooxyenase-2; NF-kB: nuclear factor kappa-B; PR-B: progesterone receptor type B.
|
31714804 |
2020 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that inflammation and MAPKs pathways respond for the abnormal expression of COX-2, which can elucidate the pathophysiology of endometriosis.
|
30773096 |
2019 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Btk inhibitor Ibrutinib prevented lesion growth, reduced mRNA expression of cyclooxygenase-2, alpha smooth muscle actin and type I collagen in the lesions and skewed activated B cells toward Bregs in the spleen and peritoneal cavity of mice with endometriosis.
|
31247078 |
2019 |
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The prevalence and immunohistologic study (Ki-67, BAF250a, COX-2) of cases of cellular and architectural atypia in endometriosis were analyzed.
|
31074246 |
2019 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, endometriotic stromal cells (ESCs; n = 3) from ectopic endometriosis lesions were cultured and incubated with/without NGF and/or Trk inhibitor K252a, followed by expression analysis of prostaglandin-endoperoxide synthase 2 (PTGS-2)/cyclooxygenase 2 (COX-2; reverse transcription quantitative real-time polymerase chain reaction and Western blot) and prostaglandin E2 (PGE2) secretion (enzyme-linked immunosorbent assay).
|
28673205 |
2018 |
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overall, the results of the study reveal the efficacy of 6-shogaol against endometriosis via effectively suppressing proliferation of the lesions and modulating angiogenesis and COX-2/NF-κB-mediated inflammatory cascades.
|
30402023 |
2018 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
For the first time, decreased expression of PTGS2 was found in cumulus cells of infertile women with endometriosis compared with controls (7.2 ± 10.5 versus 12.4 ± 15.7), which might be related to reduced levels of COX-2 in the cumulus cells of women with the disease.
|
28734688 |
2017 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, the drug also up-regulates the expression of COX-2, which has been suggested to promote the progression of endometriosis.
|
28548231 |
2017 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In a preclinical mouse model of endometriosis we demonstrated overexpression of the PGE<sub>2</sub>-signaling pathway (including COX-2, EP<sub>2</sub>, EP<sub>4</sub>) in endometriosis lesions, dorsal root ganglia (DRG), spinal cord, thalamus and forebrain.
|
28281561 |
2017 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our study establishes the involvement of MMP-2 activity via COX-2-PGE2-pAKT axis in promoting angiogenesis during endometriosis progression.
|
27695098 |
2016 |
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the endometriotic lesions, prostaglandin E2 (PGE2) produced by cyclooxygenase-2 (COX-2), binds to its EP4 receptor (EP4), and via c-Src kinase induces MMPs activation, promoting endometriosis.
|
27038655 |
2016 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The present study identified that in Brazilian women the presence of the ancestral allele, -765G, of the COX-2 gene is associated with an increased risk for development of moderate/severe endometriosis associated with fertility, and that the eutopic endometrium of women with endometriosis showed increased expression of COX-2 when compared to the control group.
|
26153366 |
2016 |
Endometriosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Higher expression of PLA2G2A, PTGS2, AKR1B1, AKR1C3 and ABCC4 was seen in 22-B endometriosis cells compared to HIESC control cells.
|
25446850 |
2015 |
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The amount of indoleamine 2,3-dioxygenase-1 (IDO1) and cyclooxygenase-2 (COX-2) in E-MenSCs co-cultured with allogenic peripheral blood mononuclear cells (PBMCs) was shown to be higher both at the gene and protein levels, and higher IDO1 activity was detected in the endometriosis group.
|
24939730 |
2014 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Because overexpression of COX-2 has been demonstrated to be a master regulator in endometriosis progression, our data demonstrate the critical function of proinflammatory cytokines and the COUP-TFII regulatory gene network in the progression of endometriosis.
|
24423359 |
2014 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Prostaglandin-endoperoxidase synthase (PTGS)1, PTGS2, prostaglandin E receptor (PTGER)1, PTGER2, PTGER3, and PTGER4 mRNA levels in endometrium of disease-free women and in eutopic and ectopic endometrium of endometriosis-affected women.
|
24423291 |
2014 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We reported that cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase (mPGES) mRNA were expressed in cases of endometriosis.
|
23252918 |
2013 |
Endometriosis
|
0.600 |
Therapeutic
|
disease |
RGD |
[Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats].
|
23406865 |
2013 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
COX-2 mRNA level in unmethylated endometrium of the endometriosis group or the control group was 2.39-fold and 2.66-fold, respectively, higher than that in the methylated endometrium of the same group (P < 0.01).
|
22608095 |
2012 |
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
By contrast, the cyclic stretch mimicking physiological peristalsis (3% elongation at 2 cycles/min) did not induce significant COX-2, mPGES-1 or PGE(2) production within 12 h. Both COX-2 and mPEGS-1 are PGE(2) synthases, and the aberrant COX-2 and PGE(2) production play important roles in the pathogenesis of endometriosis.
|
23239446 |
2012 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Because DNG inhibits aromatase and COX-2 expression as well as PGE(2) production in ESCs, these pharmacologic features might contribute to a therapeutic effect of DNG on endometriosis.
|
22130322 |
2012 |
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women.
|
22587873 |
2012 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the SHP and CDX1 expression increased by hypoxia play an active role in inducing inflammatory COX-2 expression in the pathogenesis of endometriosis.
|
21613300 |
2011 |
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Also, COX-2 gene expression and prostaglandin E(2) production were induced in those cells by increasing COX-2 promoter transcription activity, which could be attenuated by a specific p38MAPK inhibitor, suggesting a role for peritoneal fluid in the etiopathogenesis of endometriosis.
|
21145050 |
2011 |