Gastric ulcer
|
0.600 |
Biomarker
|
disease |
BEFREE |
Artesunate markedly ameliorated aspirin induced gastric injury in rats by targeting oxidative stress and COX-2 dependent as well as COX-2 independent proinflammatory signaling pathways and could have a therapeutic potential in gastric ulcer disease.
|
29397336 |
2018 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, the activation of AMPK by rebamipide may be a molecular mechanism that contributes to induction of COX-2, probably resulting in protection against gastric ulcers.
|
28011266 |
2017 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
BEFREE |
Current study was designed to understand the gastric ulcer healing mechanism of rhamnogalacturonan-I type pectic polysaccharide of black cumin (BCPP) utilizing acetic acid induced gastric ulcers in rats.BCPP fed groups at 200mg/kg b.w. for 10days showed up to 85% healing of gastric ulcers with modulation of key molecular events involved in ulcer healing process such as increase in gastric mucin content, cyclooxygenase-2 (Cox-2) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>).
|
28322956 |
2017 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent studies suggest that cyclooxygenase 2 (COX-2) inhibitors may enhance the toxic effects of anticancer drugs on tumor cells, including oral squamous cell carcinoma (OSCC), but its long-term use can cause side effects such as stomach ulcers and myocardial infarction.
|
28342204 |
2017 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
CTD_human |
Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice.
|
19066340 |
2009 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
RGD |
These results confirmed the importance of COX-2/PGE2 in the healing mechanism of gastric ulcers and further suggested that the healing-promoting action of PGE2 is mediated by the activation of EP4 receptors and is associated with VEGF expression.
|
17673547 |
2007 |
Gastric ulcer
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
We conclude that both COX-1 and COX-2 expression in the gastric mucosa are increased in the setting of gastritis and gastric ulceration.
|
15720413 |
2005 |
Gastric ulcer
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We constructed a prospective cohort study to evaluate how these two factors influence the expression of COX-2 mRNA in gastric antral, corpus mucosa, and gastric ulcer.
|
15599211 |
2005 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
LHGDN |
VEGF and COX-2 expression in surgical resections of human gastric ulcer tissue was examined immunohistochemically.
|
15246970 |
2004 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
CTD_human |
Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats.
|
12481160 |
2002 |
Gastric ulcer
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Implication of gastrin in cyclooxygenase-2 expression in Helicobacter pylori infected gastric ulceration.
|
11519793 |
2001 |
Gastric ulcer
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Both COX-1 and COX-2 are up-regulated in human gastric ulcers.
|
11136275 |
2001 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
CTD_human |
In this study, Wistar rats with gastric ulcers produced by serosal application of acetic acid (ulcer area 28 mm(2)) received daily treatment either with: (1) vehicle (saline); (2) NS-398 (10 mg/kg-d i.g.) and Vioxx (5 mg/kg-d i.g.), both, highly specific COX-2 inhibitors; (3) meloxicam (5 mg/kg-d i.g.), a preferential inhibitor of COX-2; (4) resveratrol (10 mg/kg-d i.g.), a specific COX-1 inhibitor; (5) indomethacin (5 mg/kg-d i.g); and (6) aspirin (ASA; 50 mg/kg-d i.g.), non-selective inhibitors of both COX-1 and COX-2.
|
11376495 |
2001 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
BEFREE |
Most were reported to be free of adverse gastrointestinal effects, but it should be noted that in the healing process of gastric ulcers and in sodium-restricted states, adverse effects of selective COX-2 inhibitors could be expected.
|
11028754 |
2000 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the following article, the phenotypes of the two Ptgs (genes coding for COX-1 and COX-2) knockouts are summarized, and recent studies to investigate the effects of COX deficiency on cancer susceptibility, inflammatory response, gastric ulceration, and female reproductive processes are discussed.
|
10487525 |
1999 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
CTD_human |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
|
10594344 |
1999 |
Gastric ulcer
|
0.600 |
Biomarker
|
disease |
CTD_human |
Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice.
|
9024292 |
1997 |