|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1α (MIP-1α) are important factors that increase bone resorption and hypercalcemia in adult T-cell leukemia (ATL).
|
31592701 |
2020 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, our cases provide the rationale for further research in pursuit of not only the source of immune-related PTHrP expression, but also of a causative link connecting the inflammatory milieu of immune-related pneumonitis and/or immune-related colitis with PTHrP-mediated hypercalcemia.
|
31699669 |
2019 |
|
Hypercalcemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Twenty-one patients with EPNS were detected: 16 with ectopic Cushing's syndrome (ECS), one with hypercalcaemia due to parathyroid hormone-related protein (PTHrP) secretion, three with hypercalcitonaemia and one patient with dual secretion of calcitonin and beta-human chorionic gonadotropin (β-HCG).
|
30280284 |
2019 |
|
Hypercalcemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although hypercalcemia due to PTHrP secretion has been published before, overproduction of calcitriol has not been reported yet in pediatric squamous cell skin carcinoma cases.
|
31782950 |
2019 |
|
Hypercalcemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Engineered from PTHrP (1-34), abaloparatide was made stable and overcame the loss of the anabolic window and hypercalcemia associated with TPTD.
|
31136739 |
2019 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
To describe the rapid resolution of hypercalcemia and normalization of serum PTHrP after elective termination of pregnancy, indicating that the placenta was the source of the PTHrP.
|
30032172 |
2018 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Five different activating PTH/PTH-related peptide (PTHrP) receptor (PTHR1) mutations have been reported as causes of Jansen metaphyseal chondrodysplasia (JMC), a rare disorder characterized by severe growth plate abnormalities and PTH-independent hypercalcemia.
|
29788189 |
2018 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A poor general status is frequently considered a contraindication for surgery, even in a palliative setting; however, we conclude that resection of lung cancer may lead to improved symptom control and survival when the patient's condition is induced by hypercalcemia secondary to PTHrP secretion from the tumor.
|
29997997 |
2018 |
|
Hypercalcemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hypercalcemia and high serum levels of parathyroid hormone-related protein (PTHrP) and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) titers were observed.
|
29548309 |
2018 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid Hormone-Related Protein-Induced Hypercalcemia of Pregnancy Successfully Reversed by a Dopamine Agonist.
|
29053801 |
2017 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The presented case is the first to report PTHrP-mediated hypercalcemia and primary hypogonadism in a patient with PH1.
|
29144803 |
2017 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP plays a central role in humoral hypercalcemia, and its expression has been reported to be closely associated with bone metastasis of breast carcinoma.
|
23588777 |
2013 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP and breast cancer: more than hypercalcemia and bone metastases.
|
22546075 |
2012 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP was identified as a cause of hypercalcemia in cancer patients 25 yr ago.
|
22745236 |
2012 |
|
Hypercalcemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, a single nucleotide polymorphism in CaR identified from a hypercalcemia-inducing lung SCC reduced the receptor's activation threshold leading to increased PTHrP expression and secretion.
|
21532883 |
2011 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells.
|
18621740 |
2008 |
|
Hypercalcemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Levels of parathyroid hormone-related protein were elevated in CIX and accompanied by hypercalcemia.
|
17878525 |
2007 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings furthermore suggest that the tumoral production of calcitonin and PTHrP might have contributed to the increased bone mineral storage of calcium and thus probably attenuated the development of frank hypercalcemia.
|
17188588 |
2007 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Imatinib may prolong survival time at BP even though the patients have the complication of PTHrP-mediated hypercalcemia.
|
16298826 |
2005 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma.
|
15889157 |
2005 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is produced by many tumors not associated with humoral hypercalcemia, including breast cancers.
|
12850290 |
2003 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Parathyroid hormone-related protein and hypercalcemia in patients with metastatic melanoma: case report and review.
|
12576923 |
2003 |
|
Hypercalcemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, whereas control animals routinely developed hypercalcemia due to PTHrP production, treatment with PSP-94 led to a near normalization of plasma calcium and a marked reduction in PTHrP production as determined by radioimmunoassay and immunohistochemistry.
|
12727822 |
2003 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP is the major pathogenetic factor for hypercalcemia in several malignancies including prostate cancer.
|
12586762 |
2003 |
|
Hypercalcemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Elevation of circulating plasma cytokines in cancer patients with high plasma parathyroid hormone-related protein levels.
|
14503917 |
2003 |