|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Accordingly, current dogma holds that PTHrP is upregulated in malignant primary breast tumors, but solid evidence for this assumption is missing.
|
30097435 |
2018 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Genome-wide association analysis identifies three new breast cancer susceptibility loci.
|
22267197 |
2012 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These studies implicate PTHrP in the development and growth of primary breast tumors and underscore the need for further research.
|
22546075 |
2012 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Methylation of the PTHrP P2 is a potential marker of breast cancer progression and might be used to evaluate the metastatic potential of breast tumors.
|
21775817 |
2011 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Although PTHrP is frequently expressed by breast tumors and other solid cancers, its effects on tumor progression are unclear.
|
22056386 |
2011 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells.
|
18621740 |
2008 |
|
Mammary Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
PTHrP promotes homotypic aggregation of breast cancer cells in three-dimensional cultures.
|
18035481 |
2008 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Parathyroid hormone-related protein regulates tumor-relevant genes in breast cancer cells.
|
16551631 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
[PTHrP and bone sialoprotein as prognostic markers for developing bone metastases in breast cancer patients].
|
17213971 |
2006 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
PTH-related protein upregulates integrin alpha6beta4 expression and activates Akt in breast cancer cells.
|
16965770 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Role of PTHrp and PTHrp-engaged pathways in MCF-7 cells migration/invasion.
|
16455237 |
2006 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
PTH-related protein enhances MCF-7 breast cancer cell adhesion, migration, and invasion via an intracrine pathway.
|
15023531 |
2004 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival.
|
12374685 |
2002 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Positive PTHrP staining was detected in 113 ( 64%) of the breast tumors.
|
11029801 |
2000 |
|
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In light of these previous data, we have examined whether substrates of either reconstituted basement membrane or representative collagen components of the breast tumor stroma (type I, V and OF/LB) might (i) regulate the PTHrP promoter usage and mRNA splicing patterns, (ii) modulate quantitatively the extracellular release of immunoreactive PTHrP (iPTHrP), and (iii) affect the expression of PTHrP-R.
|
10606734 |
1999 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The presence of PTHrP and its receptor in normal breast epithelium and breast carcinomas demonstrates that most breast tumours are able to respond to PTHrP.
|
9390035 |
1997 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To establish whether the localization of the PTHrP antigen reflects protein synthesis and also to investigate the role of PTHrP in metastatic disease, as part of an ongoing study, we used in situ hybridization to study the localization of PTHrP mRNA in a retrospective series of primary breast tumors and their metastatic lesions.
|
1442211 |
1992 |