SLC12A5, solute carrier family 12 member 5, 57468

N. diseases: 135; N. variants: 20
Disease: Hyperalgesia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.330 AlteredExpression phenotype BEFREE Accumulating evidence shows that nerve injury, peripheral inflammation and stress activate the spinal BDNF/TrkB signal, which results in the downregulation of KCC2 transport and expression, eventually leads to GAGAergic disinhibition and hyperalgesia. 29872336 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.330 Biomarker phenotype BEFREE Enhancing KCC2 function counteracts morphine-induced hyperalgesia. 28634406 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.330 Biomarker phenotype BEFREE In the present study, we intended to examine whether miR-92b-mediated posttranscriptional dysregulation of spinal potassium chloride cotransporter (KCC2) and vesicular γ-aminobutyric acid transporter (VGAT) plays a major role in the development and maintenance of long-term visceral hyperalgesia in neonatal zymosan-treated rats. 28885452 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.330 Biomarker phenotype CTD_human A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. 20086212 2010