PTK2, protein tyrosine kinase 2, 5747

N. diseases: 205; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 Biomarker disease BEFREE This inhibitor showed a very potent decrease of autophosphorylation of FAK in squamous cell carcinoma. 29897729 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 AlteredExpression disease BEFREE Tivantinib (ARQ-197) exhibits anti-tumor activity with down-regulation of FAK in oral squamous cell carcinoma. 25623532 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 Therapeutic disease CTD_human Focal adhesion kinase knockdown in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis via downregulating MCP-1/CCL2 expression. 25199511 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 Biomarker disease CTD_human Focal adhesion kinase knockdown in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis via downregulating MCP-1/CCL2 expression. 25199511 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 Biomarker disease CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 Therapeutic disease CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 GeneticVariation disease LHGDN An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. 17879163 2007
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 Biomarker disease LHGDN Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. 15331608 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.350 Biomarker disease BEFREE Here we used in situ hybridization to confirm chromosome 8q as the genomic location of the human fak gene and report that elevation of pp125FAK protein in cell lines derived from invasive squamous cell carcinomas is accompanied by gains in copy number of the fak gene in all cases examined. 10523844 1999