|
Premature Menopause
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of polymorphisms in microRNA machinery genes (DROSHA, DICER1, RAN, and XPO5) with risk of idiopathic primary ovarian insufficiency in Korean women.
|
23549446 |
2013 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reovirus infection of malignant N1E-115 mouse neuroblastoma cells led to significant increased expression of importin-β and exportin-5 mRNAs (qRTPCR) and proteins (immunohistochemistry) which was partially blocked by small interfering LNA oligomers directed against the reoviral genome.
|
29414394 |
2018 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We stratified 75 brain tissues from Alzheimer's disease into hyperphosphorylated tau positive or negative and did co-expression analyses and qRTPCR for importin-β and exportin-5 plus several bcl2 family members and compared the data to controls, Down's dementia and Parkinson's disease.
|
29414391 |
2018 |
|
Thyroid Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results in our case-control study also confirmed that XPO5 rs11077 was significantly associated with onset of TC (GT/GG vs TT P = 0.035, adjusted odds ratio = 1.25, 95% confidence interval = 1.02-1.54).
|
28383405 |
2017 |
|
Exfoliation Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism rs1057035 (DICER) and rs55671916 (XPO5) in the 3'-UTR of genes related to miRNA biogenesis was associated with decreased risk of PEX [OR = 0.65, 95%CI: 0.46-0.92, p = 0.014] and increased risk of PEXG [OR = 2.84, 95%CI: 1.02-7.94, p = 0.038], respectively.
|
30148417 |
2018 |
|
Adult Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Frequency distribution of BLMH, XPO5 and HFE gene polymorphisms in the South Indian population and their association with Hodgkin Lymphoma.
|
29683071 |
2018 |
|
Adult Liver Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Analysis of clinical specimens further showed that XPO5 phosphorylation is associated with poor prognosis for liver cancer patients.
|
27846390 |
2016 |
|
Childhood Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Frequency distribution of BLMH, XPO5 and HFE gene polymorphisms in the South Indian population and their association with Hodgkin Lymphoma.
|
29683071 |
2018 |
|
Medullary carcinoma of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DICER, DGCR8, and XPO5 mRNA levels were significantly overexpressed in MTC harboring RET mutations, in particular, in the presence of RET634 mutation.
|
24569963 |
2014 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Analysis of clinical specimens further showed that XPO5 phosphorylation is associated with poor prognosis for liver cancer patients.
|
27846390 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggested that the miRNA machinery gene expression-associated miR-SNPs would modify cancer outcomes; in this light, XPO5 may be an important new target for ESCC therapy.
|
29226993 |
2018 |
|
Transitional cell carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Silencing Dicer, Drosha, or Exportin 5 induced cell proliferation inhibition and apoptosis in bladder urothelial carcinoma T24 and 5637 cells.
|
22766726 |
2013 |
|
Malignant neoplasm of liver
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Analysis of clinical specimens further showed that XPO5 phosphorylation is associated with poor prognosis for liver cancer patients.
|
27846390 |
2016 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the therapeutic advantage of targeting XPO5 in prostate cancer and found that knocking down XPO5 in prostate cancer cells suppressed cellular proliferation and tumor development without significantly impacting normal fibroblast cells survival.
|
28881308 |
2017 |
|
Steroid-resistant nephrotic syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we identify in eight families with SRNS mutations in NUP93, its interaction partner NUP205 or XPO5 (encoding exportin 5) as hitherto unrecognized monogenic causes of SRNS.
|
26878725 |
2016 |
|
Thyroid carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results in our case-control study also confirmed that XPO5 rs11077 was significantly associated with onset of TC (GT/GG vs TT P = 0.035, adjusted odds ratio = 1.25, 95% confidence interval = 1.02-1.54).
|
28383405 |
2017 |
|
Carcinoma of larynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It was found that the frequency of the GT and the TT polymorphic variants of XPO5 gene were higher in LC patients than in controls (p < 0.0001 and p = 0.000183, resp.).
|
26688807 |
2015 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the therapeutic advantage of targeting XPO5 in prostate cancer and found that knocking down XPO5 in prostate cancer cells suppressed cellular proliferation and tumor development without significantly impacting normal fibroblast cells survival.
|
28881308 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Other clinical features were all considered to have no apparent effect in influencing the prognostic outcomes of advanced NSCLC patients receiving chemotherapy except lymph node metastasis (P < 0.05). miR-SNP rs11077 of XPO5 may be independently connected with the prognosis and chemotherapy response of advanced NSCLC patients, and patients with AC genotype have relatively improved prognostic outcomes and better curative effect of chemotherapy than those with AA allele of XPO5.
|
26358254 |
2016 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reovirus infection of malignant N1E-115 mouse neuroblastoma cells led to significant increased expression of importin-β and exportin-5 mRNAs (qRTPCR) and proteins (immunohistochemistry) which was partially blocked by small interfering LNA oligomers directed against the reoviral genome.
|
29414394 |
2018 |
|
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a recessive model, the XPO5 rs11077CC genotype was associated with a 32% reduced risk of CAD (OR<sub>adjusted</sub> = 0.68; CI: 0.30-0.99 p = 0.047).
|
31185329 |
2019 |
|
Urothelial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression levels of Dicer, Drosha, and Exportin 5 were determined using Real-Time qPCR in 40 patients with urothelial carcinoma of the bladder.
|
22766726 |
2013 |
|
Steroid resistant nephrotic syndrome of childhood
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we identify in eight families with SRNS mutations in NUP93, its interaction partner NUP205 or XPO5 (encoding exportin 5) as hitherto unrecognized monogenic causes of SRNS.
|
26878725 |
2016 |
|
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reovirus infection of malignant N1E-115 mouse neuroblastoma cells led to significant increased expression of importin-β and exportin-5 mRNAs (qRTPCR) and proteins (immunohistochemistry) which was partially blocked by small interfering LNA oligomers directed against the reoviral genome.
|
29414394 |
2018 |
|
Reoviral infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, productive reoviral infection is strongly correlated with elevated importin-β and exportin-5 levels which may serve as biomarkers of the disease in clinical specimens.
|
29414394 |
2018 |