PTN, pleiotrophin, 5764

N. diseases: 164; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.300 Biomarker group CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0024667
Disease: Animal Mammary Neoplasms
Animal Mammary Neoplasms 		0.300 Biomarker phenotype CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.300 Biomarker phenotype CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0205696
Disease: Anaplastic carcinoma
Anaplastic carcinoma 		0.300 Biomarker disease CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0205697
Disease: Carcinoma, Spindle-Cell
Carcinoma, Spindle-Cell 		0.300 Biomarker disease CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0205698
Disease: Undifferentiated carcinoma
Undifferentiated carcinoma 		0.300 Biomarker disease CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0205699
Disease: Carcinomatosis
Carcinomatosis 		0.300 Biomarker phenotype CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C1257925
Disease: Mammary Carcinoma, Animal
Mammary Carcinoma, Animal 		0.300 Biomarker disease CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.210 AlteredExpression disease BEFREE In this study, we evaluated the changes in PTN and Fyn protein levels and Fyn phosphorylation status in the 6-OHDA rat model of PD rendered dyskinetic with L-DOPA. 29241709 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.210 Therapeutic disease RGD Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons. 19615368 2009
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.210 AlteredExpression disease LHGDN Pleiotrophin inhibits transforming growth factor beta1-induced apoptosis in hepatoma cell lines. 18381592 2008
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.210 Biomarker disease RGD Pleiotrophin inhibits transforming growth factor beta1-induced apoptosis in hepatoma cell lines. 18381592 2008
CUI: C0149721
Disease: Left Ventricular Hypertrophy
Left Ventricular Hypertrophy 		0.200 Biomarker disease RGD Intramyocardial protein therapy with vascular endothelial growth factor (VEGF-165) induces functional angiogenesis in rat senescent myocardium. 21224495 2010
CUI: C0005398
Disease: Cholestasis, Extrahepatic
Cholestasis, Extrahepatic 		0.200 Biomarker disease RGD Factors released from cholestatic rat livers possibly involved in inducing bone marrow hepatic stem cell priming. 18225978 2008
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy 		0.200 Biomarker disease RGD Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain. 18365878 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.200 Biomarker disease RGD Conversely, we show in a rat model of myocardial infarction and in human dilated cardiomyopathy that pleiotrophin is markedly up-regulated. 17925408 2007
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Biomarker disease RGD Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages, and astrocytes after acute ischemic brain injury. 9570800 1998
CUI: C0014072
Disease: Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis 		0.200 Biomarker disease RGD Basal expression of PTN and MK mRNAs in normal spinal cords was significantly upregulated after induction of EAE. 9814819 1998
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.200 Biomarker disease RGD Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat. 8453763 1993
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE For example, circRNA_PTN has been recognized as a biomarker of human cancer and is overexpressed in glioma. 31609809 2020
CUI: C0017638
Disease: Glioma
Glioma 		0.100 Biomarker disease BEFREE For example, circRNA_PTN has been recognized as a biomarker of human cancer and is overexpressed in glioma. 31609809 2020
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE For example, circRNA_PTN has been recognized as a biomarker of human cancer and is overexpressed in glioma. 31609809 2020
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE Pleiotrophin (PTN) is involved in tumour progression, angiogenesis and metastasis. 30635982 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE A meta-analysis on the role of pleiotrophin (PTN) as a prognostic factor in cancer. 30427932 2018