PTN, pleiotrophin, 5764

N. diseases: 164; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE For example, circRNA_PTN has been recognized as a biomarker of human cancer and is overexpressed in glioma. 31609809 2020
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Population proportion of the CREB3L1<sup>+</sup>-presenting patients decreased from the control to the high-grade glioma and the population of the PTN<sup>+</sup>-presenting patients increased in low- and high-grade gliomas as compared with the control (both <i>P</i><0.05). 29531016 2018
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion. 28841413 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Pleiotrophin, in complex with the binding partners, activated glioma Rho/ROCK signaling, and ROCK inhibition decreased invasion toward SVZ NPC-secreted factors. 28823557 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN-PTPRZ1 paracrine signalling. 28569747 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Intracranial injection of RCAS-PTN did not induce glioma formation when administrated alone, but significantly enhanced RCAS-platelet derived growth factor (PDGF)B-induced gliomagenesis. 27806344 2016
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Our findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization. 26645582 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE The expression levels of MK and PTN proteins in glioma tissue were both significantly higher (both p<0.001) than those in paratumor tissues on immunohistochemistry analysis, which was confirmed by qRT-PCR analysis. 25001988 2014
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease LHGDN Heparin affin regulatory peptide/pleiotrophin negatively affects diverse biological activities in C6 glioma cells. 17881084 2008
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE In addition, PTN can induce glioma cell migration which is at least in part mediated through binding to PTPzeta/RPTPbeta. 16923162 2006
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease LHGDN Western blot analysis revealed that HB-GAM protein contents in glioma cell lines and glioblastoma tissues were 1.8 to 6.3 times higher than those in normal brain tissues. 15684595 2004
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Western blot analysis revealed that HB-GAM protein contents in glioma cell lines and glioblastoma tissues were 1.8 to 6.3 times higher than those in normal brain tissues. 15684595 2004
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE PTN did not influence the proliferation of glioma cells themselves, but stimulated [3H]thymidine incorporation into DNA of microglial cells. 12421346 2002