Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
For example, circRNA_PTN has been recognized as a biomarker of human cancer and is overexpressed in glioma.
|
31609809 |
2020 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Population proportion of the CREB3L1<sup>+</sup>-presenting patients decreased from the control to the high-grade glioma and the population of the PTN<sup>+</sup>-presenting patients increased in low- and high-grade gliomas as compared with the control (both <i>P</i><0.05).
|
29531016 |
2018 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion.
|
28841413 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pleiotrophin, in complex with the binding partners, activated glioma Rho/ROCK signaling, and ROCK inhibition decreased invasion toward SVZ NPC-secreted factors.
|
28823557 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN-PTPRZ1 paracrine signalling.
|
28569747 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Intracranial injection of RCAS-PTN did not induce glioma formation when administrated alone, but significantly enhanced RCAS-platelet derived growth factor (PDGF)B-induced gliomagenesis.
|
27806344 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization.
|
26645582 |
2015 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of MK and PTN proteins in glioma tissue were both significantly higher (both p<0.001) than those in paratumor tissues on immunohistochemistry analysis, which was confirmed by qRT-PCR analysis.
|
25001988 |
2014 |
Glioma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Heparin affin regulatory peptide/pleiotrophin negatively affects diverse biological activities in C6 glioma cells.
|
17881084 |
2008 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, PTN can induce glioma cell migration which is at least in part mediated through binding to PTPzeta/RPTPbeta.
|
16923162 |
2006 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Western blot analysis revealed that HB-GAM protein contents in glioma cell lines and glioblastoma tissues were 1.8 to 6.3 times higher than those in normal brain tissues.
|
15684595 |
2004 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Western blot analysis revealed that HB-GAM protein contents in glioma cell lines and glioblastoma tissues were 1.8 to 6.3 times higher than those in normal brain tissues.
|
15684595 |
2004 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PTN did not influence the proliferation of glioma cells themselves, but stimulated [3H]thymidine incorporation into DNA of microglial cells.
|
12421346 |
2002 |