QSOX1, quiescin sulfhydryl oxidase 1, 5768

N. diseases: 43; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 AlteredExpression phenotype BEFREE Because short hairpin knockdowns (KD) of QSOX1 have been shown to suppress tumor growth and invasion <i>in vitro</i> and <i>in vivo</i>, we hypothesized that chemical compounds inhibiting QSOX1 enzymatic activity would also suppress tumor growth, invasion, and metastasis. 31575656 2020
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 Biomarker phenotype BEFREE In addition, LLC mouse models with QSOX1 knock-down also proved that QSOX1 functions in promoting cancer metastasis. 30336636 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 AlteredExpression phenotype BEFREE A consensus is building that QSOX1 over-expression is important during tumor cell invasion, facilitating tumor cell migration at the tumor-stroma interface. 24359107 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 Biomarker phenotype BEFREE In this study, we investigate QSOX1 as a marker of breast tumor progression and evaluate the role of QSOX1 as it relates to breast tumor growth and metastasis. 23536962 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 Biomarker phenotype BEFREE Moreover, we investigated QSOX1's potential role in regulating tumor growth and metastasis using cellular models in which we overexpressed or extinguished QSOX1 and xenograft experiments. 23098186 2012