Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Patients with CLD had impaired liver function, anemia of inflammation and lower serum levels of hepcidin than control subjects.
|
31835128 |
2020 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Selenium deficiency has been linked to anemia of inflammation, which is mediated by hepcidin.
|
31597392 |
2019 |
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
1) Background: Elevated hepcidin levels have been linked to anemia of inflammation (AI).
|
31052280 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This work indicates that the crosstalk between liver hepcidin and intestinal HIF-2α plays an important role during iron overload, systemic iron deficiency, and anemia.
|
30530987 |
2019 |
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
High hepcidin levels are thought to contribute to increased iron sequestration and subsequent anaemia in CKD patients.
|
30677788 |
2019 |
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Discovery of hepcidin and elucidation of its mechanism of action and consequences of its upregulation and suppression have unraveled important insight into many hematologic disorders including anemia of CKD.
|
31477260 |
2019 |
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Tinospora cordifolia protects against inflammation associated anemia by modulating inflammatory cytokines and hepcidin expression in male Wistar rats.
|
31358831 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Deregulation of hepcidin synthesis is associated with anemia in three conditions: iron refractory iron deficiency anemia (IRIDA), the common anemia of acute and chronic inflammatory disorders, and the extremely rare hepcidin-producing adenomas that may develop in the liver of children with an inborn error of glucose metabolism.
|
31649559 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Dysregulation of hepcidin production contributes to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and non-transfused β-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic inflammatory diseases and inherited iron-refractory iron-deficiency anemia.
|
30798807 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Hepcidin/ferritin ratio, associated with both dialysis modality and inflammation, is expected to be a useful indicator of anemia in CKD.
|
30411489 |
2019 |
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we found that the increased levels of serum hepcidin were positively correlated with the severity of anemia and the imbalance of iron metabolism in anemic UC and CD patients.
|
31814801 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Hepcidin in chronic kidney disease anemia.
|
30798815 |
2019 |
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to investigate the effect of etanercept (anti-tumor necrosis factor) on anemia and hepcidin gene expression in a rat model of RA.
|
30970527 |
2019 |
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation.
|
30458168 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In recent animal studies, hepcidin knockout (KO) mice with adenine-induced CKD did not exhibit anemia and iron deficiency.
|
30991414 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Expert opinion: Hepcidin is a key regulator of iron availability and is a potential future therapeutic target for managing anemia that is associated with CKD.
|
30907175 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
|
30798817 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Serum hepcidin content is influenced by CHC disease rather than by anemia associated with or without esophageal bleeding and it could be used as a marker of early hepatic insufficiency.
|
31567713 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
All 64 patients had increased levels of serum hepcidin compared with normal controls, while patients with anemia had higher serum hepcidin than patients without anemia (85.30 ± 16.92 ng/mL vs. 53.48 ± 13.32 ng/mL, p < 0.001).
|
30923957 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the role of hepcidin in the development of anaemia and ESA resistance/hyporesponsiveness and its relation to the plasma levels of the inflammatory markers interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hsCRP).
|
30600440 |
2019 |
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
If this pathway remains unresolved, chronic overexpression of hepcidin contributes to the anemia of inflammation, a common medical condition.
|
31295319 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, excess hepcidin suppression in the setting of ineffective erythropoiesis contributes to iron-loading anemias such as β-thalassemia, whereas excess hepcidin induction contributes to iron-restricted erythropoiesis and anemia in chronic inflammatory diseases.
|
30401708 |
2019 |
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
O2 homeostasis is critically intertwined with erythropoietic response in blood loss and anemia and the hormones that modulate iron mobilization and RBC production (e.g., erythropoietin, erythroferrone, and hepcidin) are intriguing markers for the monitoring of transfusion effectiveness in acute and chronic settings.
|
31483333 |
2019 |
Anemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Baseline hepcidin >1.6 µg/L was associated with reduced risk of anemia at delivery by 49% (95% CI: 27%, 45%).
|
31624364 |
2019 |
Anemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Anaemia in TREX1 D18N mice is accompanied by increased erythropoietin (Epo), normal hepcidin levels and the TREX1 D18N mice display an inappropriate response to anaemic challenge.
|
30422000 |
2018 |