Rheumatoid Arthritis
|
0.480 |
Biomarker
|
disease |
BEFREE |
In total, 25 single nucleotide polymorphisms were found to be associated with anti-TNF treatment response in RA (19 from genome-wide association studies and 6 from the meta-analyses), and these map to genes involved in T cell function, NFκB and TNF signalling pathways (including CTCN5, TEC, PTPRC, FCGR2A, NFKBIB, FCGR2A, IRAK3).
|
28607508 |
2017 |
Rheumatoid Arthritis
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
The most significant result was obtained with rs10919563 in PTPRC, which is a confirmed RA susceptibility locus.
|
25896535 |
2016 |
Rheumatoid Arthritis
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
The PTPRC rs10919563 A allele shows a poor response to anti-TNF therapy, and the FCGR2A HH + HR genotype shows a poor response to adalimumab for RA.
|
27074847 |
2016 |
Rheumatoid Arthritis
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.
|
25834819 |
2015 |
Rheumatoid Arthritis
|
0.480 |
AlteredExpression
|
disease |
BEFREE |
Rare cells of undefined nature, detected by flow cytometry following CD45(-) enrichment, strongly expressed surface cadherin-11 (estimated 10-50cells/ml of blood) in 5/6 patients with polyarticular established disease versus 1/6 patients with early RA.
|
25173800 |
2014 |
Rheumatoid Arthritis
|
0.480 |
GeneticVariation
|
disease |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.480 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Based on a previously reported association of RA with the PTPRC genetic locus, the present study was undertaken to test established RA susceptibility variants, including PTPRC, in the prediction of response to TNF blockade in a large cohort of patients from the UK.
|
21952740 |
2012 |
Rheumatoid Arthritis
|
0.480 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
Rheumatoid Arthritis
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Of the 31 RA-associated risk alleles, a SNP at the PTPRC (also known as CD45) gene locus (rs10919563) was associated with the primary end point, a EULAR good response versus no response (odds ratio [OR] 0.55, P = 0.0001 in the multivariate model).
|
20309874 |
2010 |
Rheumatoid Arthritis
|
0.480 |
Biomarker
|
disease |
BEFREE |
Patients with PSS compared to normal subjects had significantly lower percentages of CD3+ (p less than 0.005) and CD8+ (p less than 0.05) (similar to several patients with rheumatoid arthritis also evaluated), as well as CD45R (p less than 0.05), T+DR+ (p less than 0.05), and NKH-1 (CD56) (p less than 0.0005) cells.
|
2013671 |
1991 |