|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1.
|
17028982 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
One particular protein, BARD1, seems to be an important regulator of the tumour-suppressor function of BRCA1, as well as acting as a tumour suppressor itself.
|
16633366 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In breast cancer, BARD1 expression was correlated with poor differentiation and large tumor size, established factors of poor prognosis, as well as short disease-free survival.
|
16152612 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BARD1 (BRCA1-associated RING-domain 1) is a tumor suppressor whose protein product interacts with BRCA1, and in which rare somatic and germline mutations have been reported in breast, uterine, and endometrial cancers.
|
16333312 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The BARD1 gene is mutated in a subset of breast and ovarian cancers, implicating BARD1 as a potential tumor suppressor.
|
15632137 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The BRCA1 tumor suppressor and the BARD1 protein form a stable heterodimeric complex that can catalyze the formation of polyubiquitin chains.
|
15166217 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TIEG in combination with Bard1 discriminated between N-/bad outcome from N-/good tumors with a sensitivity and specificity of 83 and 82%, respectively.
|
15218362 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We report that EWS and EWS-FLI1 interact via their common NH2 terminus with the COOH terminus of BARD1, a putative tumor suppressor, in vitro and in vivo.
|
12183411 |
2002 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A tumor-associated mutation Q564H of BARD1 is defective in apoptosis induction, thus suggesting a role of BARD1 in tumor suppression by mediating the signaling from proapoptotic stress toward induction of apoptosis.
|
11779501 |
2001 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Somatically acquired missense mutations were observed in one breast carcinoma and one endometrial tumor; in at least one of these cases, tumor formation was accompanied by loss of the wild-type BARD1 allele, following the paradigm for known tumor suppressor genes.
|
9425226 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The BARD1/BRCA1 interaction is disrupted by BRCA1 missense mutations that segregate with breast cancer susceptibility, indicating that BARD1 may be involved in mediating tumour suppression by BRCA1.
|
8944023 |
1996 |