Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, B16-LS9 cells showed a reduced tumor growth and liver metastatic activity when grafted in PTX3-overexpressing transgenic mice.
|
31487962 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we not only tested the association between PTX3 expression and the World Health Organization (WHO) tumor grading system but also evaluated overall patient survival under variable expression of PTX3 and Nrf2 in primary brain tumors (PBTs).
|
30942197 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we will summarize and discuss the scientific literature data focusing on the role of PTX3 in experimental and human tumors, including its putative translational implications.
|
29175552 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PTX3 interacts with FGF2 and other FGF family members, thus acting as a multi-FGF antagonist able to inhibit FGF-dependent neovascularization and tumor growth.
|
30443492 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
And it was found that a marked up-regulation in the expression of PTX3 in the HCC specimens, which was remarkably correlated with high serum AFP level (P = 0.006), larger tumor size (P <0.001), liver cirrhosis (P = 0.004), advanced TNM stage (P = 0.022), PVTT (P = 0.010), intra-hepatic metastases (P = 0.019), and MVI (P <0.001).
|
30087705 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The enhancement of binding between tumor and endothelial cells was observed in oleate-treated cells but not in the depletion and neutralization of PTX3 with siPTX3 and anti-PTX3 antibodies, respectively.
|
28489600 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The abundance of <i>PTX3</i> transcripts in breast tumors negatively correlated with patient survival, suggesting that <i>PTX3</i> may be a useful biomarker for stratifying BLBC patients and that targeting PTX3 may suppress tumor growth in some BLBC patients.Listen to Podcast.
|
28223415 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Conversely, PTX3 overexpression in transgenic mice or treatment with the FGF inhibitor NSC12 result in a significant inhibition of the growth and vascularization of TRAMP-C2 tumor grafts, a murine model of prostate cancer, that were paralleled by a decrease of mast cell infiltrate into the lesion.
|
29137286 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We also showed that PTX3 plays an important role in the proliferation of the tumor endothelial cells.
|
27862647 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical staining showed that increased PTX3 expression was significantly associated with tumor grade (P < 0.011) and differentiation (P < 0.019).
|
27377307 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a GBM8401 xenograft animal model, PTX3 knockdown decreases tumor growth in vivo.
|
27278519 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PTX3 expression was epigenetically regulated in selected human tumors (e.g., leiomyosarcomas and colorectal cancer) by methylation of the promoter region and of a putative enhancer.
|
25679762 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PTX3 promoted the tumor cell migratory potential, the recruitment of macrophages and their subsequent binding to gastric cancer cells.
|
25964543 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tail-vein injection animal model revealed that depletion of PTX3 decreased EGF-primed tumor cell metastatic seeding of the lungs.
|
25797258 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The identification of PTX3 provided a new insight in the interaction between host and tumor and the RI37 peptide showed a great opportunity to largely reduce the risk of invasion and metastasis of cancer and drug-resistant cancers.
|
26124179 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we demonstrate that human PTX3 overexpression in transgenic mice driven by the Tie2 promoter inhibits tumor growth, angiogenesis, and metastasis in heterotopic, orthotopic, and autochthonous FGF-dependent tumor models.
|
26267536 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Pentraxin 3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but its exact role remains unclear.
|
24457902 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data represent the first experimental evidence about a nonredundant role of the FGF/FGFR system in the modulation of the EMT process in melanoma and indicate that PTX3 or its derivatives may represent the basis for the design of novel therapeutic approaches in FGF/FGFR-dependent tumors, including melanoma.
|
24130051 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity.
|
23664694 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A panel of selected representative pro-inflammatory genes (RAGE and P2X7R, COX2, NOS2 and, PTX3) were analyzed, comparing tumor, peritumor and host normal tissues.
|
21489226 |
2011 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Aberrant methylation of the 3q25 tumor suppressor gene PTX3 in human esophageal squamous cell carcinoma.
|
22072855 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we assessed the capacity of PTX3 to antagonize FGF8b and to inhibit the vascularization and growth of steroid hormone-regulated tumors.
|
21764903 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice.
|
19794969 |
2009 |