|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Subjects with the highest PTX3 levels (≥ 1.17 ng/dl) exhibited a lower risk of metabolic syndrome (odds ratio [OR] 0.73, 95% confidence interval [CI] 0.57-0.94), overweight/obesity (OR 0.65, 95% CI 0.50-0.83), increased TG level (OR 0.66, 95% CI 0.51-0.86), and increased HDL-C level (OR 0.67, 95% CI 0.51-0.88) compared to those with the lowest PTX3 level (＜0.7 ng/dl).
|
30674758 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results support a critical role for PTX3 in the onset of obesity by promoting inflammation and limiting adipose tissue vascularization and delineate PTX3 targeting as a valuable strategy for the treatment of adipose tissue-associated inflammatory response.
|
30859179 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cardiotrophin-1 (CT-1), Titin, pentraxin (PTX-3) and soluble CD36 (sCD36) concentrations were determined in 80 cord blood samples from a) LGA pregnancies due to maternal diabetes (n = 8), overweight/obese (n = 11), excessive weight gain (n = 7), without specific pathology (n = 14), b) AGA normal pregnancies (controls, n = 40).
|
28298172 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that PTX3 plays a key role in the development of obesity by enhancing adipocyte differentiation and lipid synthesis <i>via</i> NPY/NPYR signaling.
|
30105036 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Potential Role of Aerobic Exercise-Induced Pentraxin 3 on Obesity-Related Inflammation and Metabolic Dysregulation.
|
28400677 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined that PTX3 was an important moderator of obesity, and we elucidated its mechanism, thus providing new targets and theories for obesity therapy.
|
28770376 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that concentrations of PTX3 observed in plasma are relatively independent of those produced by PBMCs ex vivo and the mechanisms associated with PTX3-mediated anti-inflammatory signaling may differ during obesity.
|
28440716 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been reported that PTX-3 is significantly associated with obesity, metabolic syndrome, and cardiovascular diseases (CVD).
|
27831642 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots and weight loss.
|
24415446 |
2014 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human preadipocyte SGBS cell line was used to study PTX3 production in response to factors that obesity entails.
|
21900125 |
2011 |