|
Alzheimer's Disease
|
0.520 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of B cell lymphoma 2 (Bcl‑2) were increased, and the expression levels of caspase‑3, Bcl‑2 associated X protein and AD‑associated proteins were decreased in the hippocampus following treatment with vildagliptin.
|
29257340 |
2018 |
|
Alzheimer's Disease
|
0.520 |
Therapeutic
|
disease |
RGD |
Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model.
|
29587274 |
2018 |
|
Alzheimer's Disease
|
0.520 |
Therapeutic
|
disease |
RGD |
CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease.
|
29777699 |
2018 |
|
Alzheimer's Disease
|
0.520 |
Therapeutic
|
disease |
RGD |
"Xiusanzhen" can regulate the expression of hippocampal Bcl-2 and Bax proteins in AD rats, which may contribute to its clinical effect in relieving AD, and the therapeutic effect depends on the integrity of the olfactory nerve pathway.
|
21585051 |
2011 |
|
Alzheimer's Disease
|
0.520 |
Biomarker
|
disease |
CTD_human |
Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease.
|
18077176 |
2008 |
|
Alzheimer's Disease
|
0.520 |
Biomarker
|
disease |
RGD |
[Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease].
|
17639989 |
2007 |
|
Alzheimer's Disease
|
0.520 |
Biomarker
|
disease |
RGD |
Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain.
|
16265626 |
2005 |
|
Alzheimer's Disease
|
0.520 |
Biomarker
|
disease |
BEFREE |
Consequently, we examined the expression of bcl-associated X (Bax) protein in AD brain.
|
8990132 |
1997 |
|
Myocardial Reperfusion Injury
|
0.500 |
Therapeutic
|
phenotype |
RGD |
[Effects of hydrogen-rich saline on endoplasmic reticulum stress during myocardial ischemia-reperfusion in rats].
|
25547710 |
2014 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
CTD_human |
Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice.
|
23090186 |
2013 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Therapeutic
|
disease |
RGD |
NMDA and AMPA receptor mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rat: ameliorating effects of curcumin.
|
23267840 |
2013 |
|
Acute kidney injury
|
0.500 |
Biomarker
|
disease |
CTD_human |
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
|
20623750 |
2011 |
|
Myocardial Reperfusion Injury
|
0.500 |
Therapeutic
|
phenotype |
RGD |
[Effects of BNP preconditioning on myocardial cell apoptosis and expressions of bcl-2 and Bax during myocardial ischemia-reperfusion injury in rats].
|
21223820 |
2010 |
|
Acute kidney injury
|
0.500 |
Therapeutic
|
disease |
RGD |
N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins.
|
20037173 |
2010 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
RGD |
The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats.
|
18991018 |
2009 |
|
Myocardial Reperfusion Injury
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Cardioprotective effects of benazepril, an angiotensin-converting enzyme inhibitor, in an ischaemia-reperfusion model of myocardial infarction in rats.
|
20026869 |
2009 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
|
10739008 |
2000 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.410 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.410 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of IQGAP3 inhibited apoptosis in BC cells, along with increased expression of phosphorylated extracellular signal-regulated kinases 1/2 (p-ERK1/2) and B cell lymphoma 2 (Bcl2) and decreased Bcl-2-associated X protein (Bax) expression, which was counteracted by Kaempferol treatment.
|
31605603 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<i>Results:</i> The expression of miR-125a-5p in breast cancer cell lines, MDA-MB-157 cells, MDA-MB-361 cells and MDA-MB-415 cells, was significantly lower than that in normal breast epithelial cells, MCF-10A cells; The proliferation and invasion ability of MDA-MB-157 cells transfected with miR-125a-5p were significantly inhibited, and the apoptosis rate was significantly increased; Since GAB2 knocked down, the proliferation and invasion ability of MDA-MB-157 cells were significantly inhibited, while the apoptosis rate was significantly increased, the Bax protein expression was significantly down-regulated, and the Bcl-2 protein expression was significantly up-regulated; The dual-luciferase reporter assay demonstrated that miR-125a-5p can specifically target GAB2.
|
31698596 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the effect of amygdalin on the cell death and the level of pro-apoptotic Bax protein and anti-apoptotic Bcl-2 protein in SK-BR-3 human breast cancer cell line.
|
31583572 |
2019 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Silica Nanoparticles Provoke Cell Death Independent of p53 and BAX in Human Colon Cancer Cells.
|
31426331 |
2019 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of IQGAP3 inhibited apoptosis in BC cells, along with increased expression of phosphorylated extracellular signal-regulated kinases 1/2 (p-ERK1/2) and B cell lymphoma 2 (Bcl2) and decreased Bcl-2-associated X protein (Bax) expression, which was counteracted by Kaempferol treatment.
|
31605603 |
2019 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the effect of amygdalin on the cell death and the level of pro-apoptotic Bax protein and anti-apoptotic Bcl-2 protein in SK-BR-3 human breast cancer cell line.
|
31583572 |
2019 |