|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
To study the function of different components of the uPA-uPAR system on behavior and epileptogenesis, and to complement our previous studies on naïve and injured mice deficient in the uPA-encoding gene Plau or the uPAR-encoding gene Plaur, we analyzed the behavioral phenotype, seizure susceptibility, and perineuronal nets surrounding parvalbumin-positive inhibitory interneurons in Plau and Plaur (double knockout dKO) mice.
|
30836238 |
2019 |
|
Seizures
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrations in glutamatergic neurotransmission has been implicated in some seizure models, and we have recently reported that reduced cortical AMPA receptor (AMPAR) expression (predominantly GluA4- containing AMPARs) in parvalbumin-containing (PV<sup>+</sup>) inhibitory interneurons, could underlie seizure generation in the stargazer mutant mouse.
|
30593850 |
2019 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
To test this, we used a pentylenetetrazole- (PTZ-) kindling model mouse to investigate changes to hippocampal parvalbumin- (PV-) positive neurons, extracellular matrix molecules, and perineuronal nets (PNNs) after the last kindled seizure.
|
31827499 |
2019 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Those data demonstrated that pharmaco-genetic seizure attenuation through targeting parvalbumin neurons rather than pyramidal neurons may be a novel and relatively safe approach for treating refractory TLE.
|
29894753 |
2018 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Selective Silencing of Hippocampal Parvalbumin Interneurons Induces Development of Recurrent Spontaneous Limbic Seizures in Mice.
|
28733354 |
2017 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Previous research has shown that in vivo on-demand optogenetic stimulation of inhibitory interneurons expressing parvalbumin (PV) is sufficient to suppress seizures in a mouse model of temporal lobe epilepsy (TLE).
|
28151564 |
2017 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, PV neurons are highly vulnerable to status epilepticus (SE, prolonged seizure activity), although the underlining mechanism remains to be clarified.
|
28919853 |
2017 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Notably, PV, but not SOM, neurons modulate somatosensory behavior and disrupt seizures.
|
28591583 |
2017 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Inhibiting PV+ and SOM+ interneurons had mixed effects on seizure initiation but consistently reduced seizure duration.
|
28041880 |
2017 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Seizure frequency significantly correlated with the loss of GABAergic interneurons in or adjacent to the granule cell layer, but not with the loss of parvalbumin-positive interneurons.
|
28425097 |
2017 |
|
Seizures
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Hyperthermic seizure induces persistent alteration in excitability of the dentate gyrus in immature rats.
|
18495095 |
2008 |