Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma.
|
23448979 |
2013 |
Central neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma.
|
23448979 |
2013 |
Childhood Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma.
|
23448979 |
2013 |
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
Overexpression of h-prune in breast cancer is correlated with advanced disease status.
|
15671547 |
2005 |
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND VARIABLE BRAIN ANOMALIES
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment.
|
28334956 |
2017 |
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, AND VARIABLE BRAIN ANOMALIES
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment.
|
28334956 |
2017 |
Muscle hypotonia
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment.
|
28334956 |
2017 |
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The h-prune gene is involved in cellular motility and metastasis formation in breast cancer through interacting with the nm23-H1 protein.
|
15671547 |
2005 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The h-prune gene is involved in cellular motility and metastasis formation in breast cancer through interacting with the nm23-H1 protein.
|
15671547 |
2005 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
The h-prune gene is involved in cellular motility and metastasis formation in breast cancer through interacting with the nm23-H1 protein.
|
15671547 |
2005 |
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The h-prune protein is a member of the DHH protein superfamily, and its overexpression in breast, colorectal and gastric cancers correlates with depth of invasion and degree of lymph-node metastasis.
|
17952613 |
2007 |
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The h-prune protein is a member of the DHH protein superfamily, and its overexpression in breast, colorectal and gastric cancers correlates with depth of invasion and degree of lymph-node metastasis.
|
17952613 |
2007 |
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The h-prune protein is a member of the DHH protein superfamily, and its overexpression in breast, colorectal and gastric cancers correlates with depth of invasion and degree of lymph-node metastasis.
|
17952613 |
2007 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The expression of h-prune (human homolog of Drosophila prune protein; HGNC13420), an exopolyphosphatase, is correlated with progression and aggressiveness in several cancers and promotes migration and invasion.
|
27037526 |
2016 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The identification of these two modes of inhibition of formation of the nm23-H1-h-prune protein complex pave the way toward new challenges, including translational studies using IC261 or this competitive peptide 'in vivo' to inhibit cellular motility induced by nm23-H1-h-prune complex formation during progression of breast cancer.
|
17906697 |
2008 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
The identification of these two modes of inhibition of formation of the nm23-H1-h-prune protein complex pave the way toward new challenges, including translational studies using IC261 or this competitive peptide 'in vivo' to inhibit cellular motility induced by nm23-H1-h-prune complex formation during progression of breast cancer.
|
17906697 |
2008 |
Neurodegenerative Disorders
|
0.020 |
GeneticVariation
|
group |
BEFREE |
This novel feature expands the clinical consequences of PRUNE mutations and allow to converge PRUNE syndrome with previous descriptions of neurodevelopmental/neurodegenerative disorders linked to altered microtubule dynamics.
|
29307700 |
2018 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
This series of events suggests that the Nm23-H1/h-Prune protein complex regulates cancer progression and that its specific impairment could be a new therapeutic strategy in oncology.
|
25138575 |
2015 |
Developmental Disabilities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We describe an additional patient with homozygous PRUNE mutation who presented with spinal muscular atrophy phenotype, in addition to the already known brain developmental disorder.
|
29307700 |
2018 |
Sarcoma
|
0.010 |
Biomarker
|
group |
BEFREE |
We found amplification of PRUNE in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
|
11687967 |
2001 |
Malignant neoplasm of soft tissue
|
0.010 |
Biomarker
|
group |
BEFREE |
We found amplification of PRUNE in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
|
11687967 |
2001 |
leiomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found amplification of PRUNE in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
|
11687967 |
2001 |
Malignant Fibrous Histiocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found amplification of PRUNE in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
|
11687967 |
2001 |
liposarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found amplification of PRUNE in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
|
11687967 |
2001 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We outline here the clinical importance of targeting of the Nme-1 (NDPK-A)-Prune-1 protein complex in cancer, where an imbalance in the formation of this protein-protein complex can result in inhibition of tumor progression.
|
29449633 |
2018 |