Maple Syrup Urine Disease
|
0.520 |
Biomarker
|
disease |
CTD_human |
We conclude that BCAT-2 deficiency in the mouse can cause a disease that mimics human MSUD.
|
14755340 |
2004 |
Maple Syrup Urine Disease
|
0.520 |
Biomarker
|
disease |
BEFREE |
We conclude that BCAT-2 deficiency in the mouse can cause a disease that mimics human MSUD.
|
14755340 |
2004 |
Maple Syrup Urine Disease
|
0.520 |
Biomarker
|
disease |
MGD |
We conclude that BCAT-2 deficiency in the mouse can cause a disease that mimics human MSUD.
|
14755340 |
2004 |
Classic Maple Syrup Urine Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.
|
14755340 |
2004 |
Intermittent Maple Syrup Urine Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.
|
14755340 |
2004 |
Maple Syrup Urine Disease, Thiamine Responsive
|
0.300 |
Biomarker
|
disease |
CTD_human |
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.
|
14755340 |
2004 |
Intermediate Maple Syrup Urine Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.
|
14755340 |
2004 |
Precancerous Conditions
|
0.300 |
Biomarker
|
group |
CTD_human |
Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.
|
19233941 |
2009 |
Condition, Preneoplastic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.
|
19233941 |
2009 |
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DARC (Duffy) and BCAM (Lutheran) reduced expression in thyroid cancer.
|
23168236 |
2013 |
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DARC (Duffy) and BCAM (Lutheran) reduced expression in thyroid cancer.
|
23168236 |
2013 |
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DARC (Duffy) and BCAM (Lutheran) reduced expression in thyroid cancer.
|
23168236 |
2013 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Another carcinogenesis-associated antigen is Lutheran or BCAM (basal cell adhesion molecule), a surface glycoprotein that acts as a receptor for the extracellular matrix protein, laminin.
|
23168236 |
2013 |
Valinemia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
BCAT2 gene mutations can cause hypervalinemia and hyperleucine-isoleucinemia, which are associated with brain white matter lesions.
|
25653144 |
2015 |
Hyperleucine-Isoleucinemia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
BCAT2 gene mutations can cause hypervalinemia and hyperleucine-isoleucinemia, which are associated with brain white matter lesions.
|
25653144 |
2015 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
Biomarker
|
disease |
BEFREE |
Loss of Bcat1 and Bcat2, the enzymes responsible for BCAA use, impairs NSCLC tumor formation, but these enzymes are not required for PDAC tumor formation, arguing that tissue of origin is an important determinant of how cancers satisfy their metabolic requirements.
|
27609895 |
2016 |
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of Bcat1 and Bcat2, the enzymes responsible for BCAA use, impairs NSCLC tumor formation, but these enzymes are not required for PDAC tumor formation, arguing that tissue of origin is an important determinant of how cancers satisfy their metabolic requirements.
|
27609895 |
2016 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
The suitability of silencing one of this enzymes (branched chain amino acid transaminase 2; BCAT2) with therapeutic effects was tested experimentally on the breast cancer cell line MCF-7 and primary cell culture of breast tumor (BCC), leading to lower cell proliferation.
|
28798381 |
2017 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The suitability of silencing one of this enzymes (branched chain amino acid transaminase 2; BCAT2) with therapeutic effects was tested experimentally on the breast cancer cell line MCF-7 and primary cell culture of breast tumor (BCC), leading to lower cell proliferation.
|
28798381 |
2017 |
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The suitability of silencing one of this enzymes (branched chain amino acid transaminase 2; BCAT2) with therapeutic effects was tested experimentally on the breast cancer cell line MCF-7 and primary cell culture of breast tumor (BCC), leading to lower cell proliferation.
|
28798381 |
2017 |
Experimental Organism Basal Cell Carcinoma
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The suitability of silencing one of this enzymes (branched chain amino acid transaminase 2; BCAT2) with therapeutic effects was tested experimentally on the breast cancer cell line MCF-7 and primary cell culture of breast tumor (BCC), leading to lower cell proliferation.
|
28798381 |
2017 |
Carcinoma, Basal Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
The suitability of silencing one of this enzymes (branched chain amino acid transaminase 2; BCAT2) with therapeutic effects was tested experimentally on the breast cancer cell line MCF-7 and primary cell culture of breast tumor (BCC), leading to lower cell proliferation.
|
28798381 |
2017 |
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We report a multistage approach combining collisional activation and 193 nm ultraviolet photodissociation (UVPD) to characterize single amino acid variants of the human mitochondrial enzyme branched-chain amino acid transferase 2 (BCAT2), a protein implicated in chemotherapeutic resistance in glioblastoma tumors.
|
30016590 |
2018 |