RAD21, RAD21 cohesin complex component, 5885

N. diseases: 192; N. variants: 19
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 Biomarker disease BEFREE Taken together, our research systematically characterized the regulatory cascades of HNF4A, HSF1, MECP2 and RAD21 in colorectal cancer metastasis. 30546056 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 AlteredExpression disease BEFREE Elevated RAD21 expression tracks with reactivation of L1 expression in human sporadic CRC, implicating cohesin-mediated L1 expression in global genomic instability and gene dysregulation in cancer. 25464844 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 AlteredExpression disease BEFREE A retrospective observation study examined RAD21 expression in 652 CRCs using a tissue microarray approach. 24548858 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 GeneticVariation disease BEFREE Compared with the major homozygotes at the Arg326Gln SNP in PTPRJ, a likely homologue of the mouse SCC1 (susceptible to colon cancer), Arg/Gln or Gln/Gln genotypes exhibited an increased colorectal cancer risk with adjusted odds ratios (aOR) of 1.71 (P = 0.021) and 3.74 (P = 4.14 x 10(-4)), respectively. 19672627 2010
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 Biomarker disease BEFREE Additional studies are warranted to study possible PTPRJ-interacting loci, which are observed with Scc1 in the mouse models for CRC susceptibility. 18843023 2008