RAD51C, RAD51 paralog C, 5889

N. diseases: 162; N. variants: 96
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease BEFREE We found that MA-17 also down-regulated DNA homologous recombination and the Fanconi anemia pathway (FANCA, BRCA1, and RAD51C) in A549 cells. 30793218 2019
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease BEFREE Expanding the FANCO/RAD51C associated phenotype: Cleft lip and palate and lobar holoprosencephaly, two rare findings in Fanconi anemia. 29278735 2018
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease GENOMICS_ENGLAND Germline Genetic Predisposition to Hematologic Malignancy. 28297620 2017
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease BEFREE In-silico analysis showed that the predicted gene targets are ATRIP, ATR, WDR48, RAD51C and FANCA genes which are involved in the Fanconi Anemia/BRCA pathway. 28544907 2017
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE The RAD51C missense mutation p.Arg258His has previously been identified in a homozygous state in a patient with Fanconi anemia. 25154786 2015
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE Mutations in downstream Fanconi anemia (FA) pathway genes, BRCA2, PALB2, BRIP1 and RAD51C, explain part of the hereditary breast cancer susceptibility, but the contribution of other FA genes has remained questionable. 24989076 2015
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE Notably, we find that Fanconi anemia (FA)-like disorder and breast and ovarian cancer patient derived mutations of RAD51C fails to protect replication fork, exhibit under-replicated genomic regions and elevated micro-nucleation. 26354865 2015
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE As further evidence for the functional importance of the HR complex, RAD51C mutants that are associated with cancer susceptibility and FA also display decreased complex formation with PALB2. 24141787 2014
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE RAD51C plays an important role in the double-strand break repair pathway and a biallelic missense mutation in the RAD51C gene was found in a Fanconi anemia-like disorder. 22725699 2013
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease BEFREE Some of the genes causing the Fanconi anemia (FA) syndrome, such as BRCA2, BRIP1, PALB2, and RAD51C, are associated with high or moderate risk of developing breast cancer. 22383991 2012
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease BEFREE An increased cancer risk has been firmly established for carriers of mutations in FANCD1/BRCA2, FANCJ/BRIP1, FANCN/PALB2, RAD51C/FANCO and link the FA pathway to inherited breast and ovarian cancer. 22829014 2012
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease GENOMICS_ENGLAND Together, these results unravel the critical role of RAD51C in the FA pathway of ICL repair and as a tumor suppressor. 22167183 2012
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease BEFREE Together, these results unravel the critical role of RAD51C in the FA pathway of ICL repair and as a tumor suppressor. 22167183 2012
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease BEFREE RAD51C, a RAD51 paralogue involved in homologous recombination, is a recently established Fanconi anemia and breast cancer predisposing factor. 21750962 2011
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE A homozygous mutation in the RAD51C gene was recently found to cause Fanconi anemia-like disorder. 21616938 2011
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE One recent study identifies biallelic mutation in RAD51C leading to Fanconi anemia-like disorder. 20952512 2010
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease GENOMICS_ENGLAND We have identified a homozygous missense mutation in the RAD51C gene in a consanguineous family with multiple severe congenital abnormalities characteristic of FA. 20400963 2010
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease BEFREE In this review, we discuss the recent progress in the study of the FA pathway, such as the identification of new FANCM-binding partners and the identification of RAD51C and FAN1 (Fanconi-associated nuclease 1) as new FA pathway-related proteins. 20713514 2010
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk. 20428093 2010
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease CTD_human We have identified a homozygous missense mutation in the RAD51C gene in a consanguineous family with multiple severe congenital abnormalities characteristic of FA. 20400963 2010
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 GeneticVariation disease BEFREE We have identified a homozygous missense mutation in the RAD51C gene in a consanguineous family with multiple severe congenital abnormalities characteristic of FA. 20400963 2010
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia
0.600 Biomarker disease GENOMICS_ENGLAND How the fanconi anemia pathway guards the genome. 19686080 2009