|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The RAD51C c.571 + 4A > G variant segregates with HBOC, with heterozygotes sharing a 5.07 Mbp haplotype.
|
31782267 |
2020 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results increase our knowledge about the RAD51C and RAD51D mutation spectrum and support the notion that these genes should be included in the gene panel testing performed on patients with hereditary breast and ovarian cancer syndrome.
|
29409816 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Mutational analysis of RAD51C and RAD51D genes in hereditary breast and ovarian cancer families from Murcia (southeastern Spain).
|
29409816 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
Biomarker
|
disease |
BEFREE |
Burden tests performed in both patients and the French Exome Project population confirmed the association of PVs of BRCA1, BRCA2, PALB2, and RAD51C with HBOC.
|
29988077 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer.
|
29922827 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer.
|
29922827 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes.
|
28829762 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair.
|
26848151 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
|
26681312 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA.
|
27230542 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.
|
26740214 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.
|
26976419 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in RAD51C have been identified in about 1% of hereditary breast and ovarian cancer families.
|
25470109 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
|
26261251 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Identification of a breast cancer family double heterozygote for RAD51C and BRCA2 gene mutations.
|
25154786 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
RAD51C mutation screening in high-risk patients from Serbian hereditary breast/ovarian cancer families.
|
26406419 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
|
26261251 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Genetic testing for RAD51C mutations: in the clinic and community.
|
25470109 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently, RAD51C, a new Fanconi Anemia gene, essential for homologous recombination repair, has been reported to be a rare hereditary breast and ovarian cancer susceptibility gene.
|
25086635 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers.
|
24993905 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Deleterious and missense mutations of RAD51C have recently been suggested to modulate the individual susceptibility to hereditary breast and ovarian cancer and unselected ovarian cancer, but not unselected breast cancer (BrC).
|
25343521 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families.
|
25086635 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GermlineCausalMutation
|
disease |
ORPHANET |
Consequently, we have performed a large RAD51C mutation screen of hereditary breast and ovarian cancer families, and the first study of unselected patients diagnosed with ovarian cancer.
|
21990120 |
2012 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Consequently, we have performed a large RAD51C mutation screen of hereditary breast and ovarian cancer families, and the first study of unselected patients diagnosed with ovarian cancer.
|
21990120 |
2012 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Germline RAD51C mutations confer susceptibility to ovarian cancer.
|
22538716 |
2012 |