This analysis revealed that 8 genetic variants (<i>CFH, ARMS2, IL-8, TIMP3, SLC16A8, RAD51B, VEGFA</i> and <i>COL8A1</i>) were significantly associated with AMD susceptibility.
Among genetic variables, SNPs of CFH, ARMS2, IL-8, TIMP3, SLC16A8, RAD51B, VEGFA and COL8A1 were significantly associated with the risk of AMD in the Italian cohort.
We concluded that the risk of developing AMD exhibits dose dependency as well as an epistatic combined effect in rs17105278 T>C and rs4902566 C>T carriers and that the elevated risk for rs17105278 T>C carriers may be due to decreased transcription of RAD51B.