|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that crossing TGFβR2ΔDC mice with a Rag1-/- background eliminates all symptoms of colitis and that adoptive transfer of unfractionated CD3+ splenocytes is sufficient to induce progressive colitis in Rag1-/-TGFβR2ΔDC mice.
|
31559420 |
2020 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistently, in contrast to WT Treg cells, Bcl10-deficient Treg cells could not protect Rag1-deficient mice from T-cell transfer-induced colitis.
|
31595055 |
2019 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
RAG1-deficient mice expressing TNFAIP3 in intestinal epithelial cells (TRAG mice) spontaneously developed 100% penetrant, early-onset colitis that was limited to the colon and dependent on intestinal microbes but was not transmissible to co-housed littermates.
|
29988117 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRIM21<sup>-/-</sup>CD45RB<sup>high</sup>CD4<sup>+</sup> T cells reconstituted into recombination-activating gene (Rag1)<sup>-/-</sup> mice induced more severe colitis than in wild-type control mice.
|
29113905 |
2018 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rag1-/- mice were transferred with T naïve cells [CD4+ CD62L+] from TNAP+/- or WT mice and developed colitis, which was attenuated in the group receiving TNAP+/- cells.
|
28039309 |
2017 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we evaluated the protective effect of Ficz on colitis in RAG1 mice injected with naïve or Smad7-overexpressing T cells.
|
26818761 |
2016 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that the NF-κB protein c-Rel regulates the inflammatory potential of colonic IFN-γ(+)Thy1(+) ILCs to induce anti-CD40-mediated colitis in rag1(-/-) mice.
|
25100292 |
2015 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Notch-1 signaling pathway is responsible for homeostatic tight junction expression in vitro, and promotes barrier function in vivo in the RAG1-adoptive transfer model of colitis.
|
24424521 |
2014 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
C57Bl6 wild-type (control), IDO1-/-, Rag1-/-, and Rag1/IDO1 double-knockout mice were exposed to azoxymethane and dextran sodium sulfate to induce colitis and tumorigenesis.
|
23669411 |
2013 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cotransfer of CD4(+)CD45RB(lo) cells from Il10(-/-)/hIL10BAC mice rescued Rag1(-/-) mice from colitis, further suggesting that CD4(+) T cells represent a protective source of hIL-10 in the colon.
|
22753934 |
2012 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the colitis induced by transfer of T(reg) cell-depleted CD45RB(lo) CD4(+) T cells into Rag1 KO mice was characterized by reduced Th1 and increased Th17 cytokine messenger RNA levels in the colon as compared with the colitis induced by transfer of CD45RB(hi) T cells.
|
21518800 |
2011 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adoptive transfer of naive T cells into RaW mice caused more rapid and severe colitis than in Rag1(-/-), indicating that the epithelial defect results in an intestinal microenvironment conducive to T-cell activation.
|
21107311 |
2011 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the contribution of these glycans to the development of colitis induced by CD4(+)CD45RB(high) T cell transfer to Rag1(-/-) mice.
|
16210648 |
2005 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we observed that administration of Toll-like receptor 9 (TLR9) agonists suppressed the severity of experimental colitis in RAG1-/- but not in SCID mice.
|
15765149 |
2005 |
|
Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, adoptive transfer of c-Maf transgenic CD4(+)CD62L(+) T cells in RAG-1-deficient mice resulted in an IL-4-dependent inability to induce colitis and suppressed colitis activity induced by wild-type CD4(+)CD62L(+) T cells.
|
15322210 |
2004 |