|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, in immunodeficient B6/ Rag1 <sup>-/-</sup> and NOG mice, the same treatment failed to control tumor growth, further proving that the attenuation of tumor growth by tumor acidity modulation was attributable to the activation of tumor-infiltrating immune cells.
|
30943039 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
More importantly, the tumor growth inhibition effect of NPsorafenib was dramatically reduced in B16-F10 bearing Rag1-/- mice which are adaptive immune cell defective, indicating that the antitumor effects of NPsorafenib are dependent on the adaptive immune cells.
|
29512660 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Serial intraperitoneal injection of primary tumor into both BALB/c and RAG-1-deficient hosts led to the successful propagation of lymphoma.
|
26584567 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumors grew similarly between C57BL/6 and Rag1(-/-) C57BL/6 mice.
|
24700450 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, depletion of NK1.1+ cells resulted in enhanced tumor outgrowth in both wild-type and Rag1(-/-) mice, showing an important role for NK cells in the natural anti-NBL immune response.
|
24038106 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NSG and NRG mice more readily support growth of human primary colon tumor fragments than do NOD-scid, NOD-Rag1 (null) mice and maintain tumor architectural integrity in the primary recipient and through subsequent transplant generations.
|
24798995 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Active MT4-MMP triggered an angiogenic switch at day 7 after tumor implantation and drastically accelerated subcutaneous tumor growth as well as lung colonization in recombination activating gene-1-deficient mice.
|
22262494 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Exogenous rIL-9 inhibited tumor growth in Rag1(-/-) mice but not in mast-cell-deficient mice, suggesting that the targets of IL-9 in this setting include mast cells but not T or B cells.
|
22772464 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Stable transfection of MT4-MMP cDNA in human breast adenocarcinoma MDA-MB-231 cells does not affect in vitro cell proliferation or invasion but strongly promotes primary tumor growth and associated metastases in RAG-1 immunodeficient mice.
|
16707440 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To evaluate the expression of the Tie2/Tek tyrosine kinase receptor in tumor blood vessels, we examined Tie2lacZ(+)/RAG1(-) mice.
|
16314485 |
2005 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
They further show that VavP-MYC17 mice that are devoid of mature T cells (and B cells) because of genetic deficiency in Rag1 recombinase develop neoplasms of three distinct blood cell lineages: pre-T cells, pro-B cells, and macrophages.
|
15782131 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor growth of HCT116(16K) cells implanted into Rag1(-/-) mice was inhibited 63% in four separate experiments compared with tumors formed from HCT116(wt) or HCT116(vector) cells.
|
11585777 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In experimental B-cell infections, Epstein-Barr virus induced sustained expression of V(D)J recombinase-activating genes RAG1 and RAG2, whose aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms.
|
7494341 |
1995 |