Cocaine Dependence
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
These findings have led to the development of recombinant butyrylcholinesterase mutants and viral gene therapy to combat cocaine addiction, along with in-depth studies on the significance of butyrylcholinesterase in obesity.
|
31702488 |
2020 |
Cocaine Dependence
|
0.370 |
Biomarker
|
disease |
BEFREE |
This brief review examines some key phenomena and considers means of modulating BChE as treatments for cocaine addiction, anxiety, aggression, and obesity.
|
29535625 |
2018 |
Cocaine Dependence
|
0.370 |
Biomarker
|
disease |
BEFREE |
Butyrylcholinesterase (BChE) gene therapy is emerging as a promising concept for treatment of cocaine addiction.
|
25814464 |
2015 |
Cocaine Dependence
|
0.370 |
Therapeutic
|
disease |
CTD_human |
Butyrylcholinesterase (BChE) gene therapy is emerging as a promising concept for treatment of cocaine addiction.
|
25814464 |
2015 |
Cocaine Dependence
|
0.370 |
Biomarker
|
disease |
BEFREE |
In continuing efforts to develop gene transfer of human butyrylcholinesterase (BChE) as therapy for cocaine addiction, we conducted wide-ranging studies of physiological and metabolic safety.
|
24892251 |
2014 |
Cocaine Dependence
|
0.370 |
Biomarker
|
disease |
BEFREE |
Cocaine hydrolase gene transfer of mutated human butyrylcholinesterase (BChE) is evolving as a promising therapy for cocaine addiction.
|
24085526 |
2014 |
Cocaine Dependence
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes.
|
24312228 |
2013 |
Cocaine Dependence
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction.
|
23840704 |
2013 |
Cocaine Dependence
|
0.370 |
Therapeutic
|
disease |
CTD_human |
Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage.
|
22935511 |
2013 |
Cocaine Dependence
|
0.370 |
Therapeutic
|
disease |
CTD_human |
Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice.
|
22960160 |
2013 |
Cocaine Dependence
|
0.370 |
Therapeutic
|
disease |
CTD_human |
Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity.
|
23000451 |
2013 |
Cocaine Dependence
|
0.370 |
Therapeutic
|
disease |
CTD_human |
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
|
20971807 |
2011 |
Cocaine Dependence
|
0.370 |
Therapeutic
|
disease |
CTD_human |
Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.
|
20060817 |
2010 |
Cocaine Dependence
|
0.370 |
Therapeutic
|
disease |
CTD_human |
An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties.
|
18514640 |
2008 |
Cocaine Dependence
|
0.370 |
Therapeutic
|
disease |
CTD_human |
Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.
|
18292872 |
2008 |