beta Thalassemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It was suggested that segregation distortion is not a mechanism which contributes to the maintenance of polymorphism in the beta-thalassemia system in the population of the Ferrara area.
|
930927 |
1977 |
beta^+^ Thalassemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It was suggested that segregation distortion is not a mechanism which contributes to the maintenance of polymorphism in the beta-thalassemia system in the population of the Ferrara area.
|
930927 |
1977 |
Fragile X Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Such a segregation distortion is difficult to assess for the fra(X) syndrome because of incomplete penetrance, variable expression and probable ascertainment biases.
|
3177475 |
1988 |
Narcolepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data show that there is no significant segregation distortion of the DR2/DQw1 haplotype in Japanese patients with narcolepsy.
|
3263961 |
1988 |
leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the existence of another genetic region linked to the MHC, causing segregation distortion, and containing recessive leukemia susceptibility genes may be postulated.
|
1610974 |
1992 |
Childhood Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the existence of another genetic region linked to the MHC, causing segregation distortion, and containing recessive leukemia susceptibility genes may be postulated.
|
1610974 |
1992 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the 50 diabetic sib sets, and independently of the Italian and British groups of affected sib pairs, revealed no segregation distortion between the marker locus and NIDDM.
|
1446805 |
1992 |
Cystic Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Single sperm typing can address questions about segregation distortion in man, and it is unlikely that sex ratio distortion for CF carriers is due to events which occur pre-fertilisation.
|
7684944 |
1993 |
Episodic Kinesigenic Dyskinesia 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
The main purpose of the study was to determine if PKD shows any segregation distortion and to obtain new estimates of the age-dependent penetrance.
|
8349100 |
1993 |
Progressive cone-rod dystrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage of cone-rod retinal dystrophy to chromosome 19q and evidence for segregation distortion.
|
8162077 |
1994 |
Cone-Rod Dystrophy 2
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of a large cone-rod dystrophy pedigree suggested that inheritance within the family was influenced by meiotic drive (p = 0.008), a rare segregation distortion in human genetics.
|
8162077 |
1994 |
Cone-Rod Dystrophies
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of a large cone-rod dystrophy pedigree suggested that inheritance within the family was influenced by meiotic drive (p = 0.008), a rare segregation distortion in human genetics.
|
8162077 |
1994 |
Rod-Cone Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of a large cone-rod dystrophy pedigree suggested that inheritance within the family was influenced by meiotic drive (p = 0.008), a rare segregation distortion in human genetics.
|
8162077 |
1994 |
POLYDACTYLY, POSTAXIAL
|
0.010 |
Biomarker
|
disease |
BEFREE |
Segregation distortion in the offspring of Afro-American fathers with postaxial polydactyly.
|
7726178 |
1995 |
Myotonic Dystrophy
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
This suggests that any greater amount of segregation distortion at the myotonic dystrophy locus must result from events following sperm ejaculation.
|
8808606 |
1996 |
Myotonic Dystrophy
|
0.040 |
Biomarker
|
disease |
BEFREE |
Segregation distortion of the CTG repeats at the myotonic dystrophy locus.
|
8659513 |
1996 |
Myotonic Dystrophy
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The concept of segregation distortion, where there is preferential transmission of the larger allele at the DM locus, has been put forward to explain partially the maintenance of DM in the population.
|
9863607 |
1998 |
Myotonic Dystrophy
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Dynamic balance of segregation distortion and selection maintains normal allele sizes at the myotonic dystrophy locus.
|
9401353 |
1998 |
Learning Disabilities
|
0.010 |
Biomarker
|
disease |
BEFREE |
FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability.
|
9435259 |
1998 |
Immunoglobulin A deficiency (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition.
|
10090895 |
1999 |
Claw hand
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Fine mapping of the split-hand/split-foot locus (SHFM3) at 10q24: evidence for anticipation and segregation distortion.
|
10330351 |
1999 |
Split foot
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Fine mapping of the split-hand/split-foot locus (SHFM3) at 10q24: evidence for anticipation and segregation distortion.
|
10330351 |
1999 |
Dentatorubral-Pallidoluysian Atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, the segregation ratio of single sperm with an expanded allele to ones with a normal allele is not statistically different ( P = 0.161) from the expected 1:1 segregation ratio, and thus segregation distortion of expanded alleles in meiosis in male patients with DRPLA was not demonstrated.
|
9949204 |
1999 |
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that antioxidant defence is altered in the schizophrenic hippocampus and suggest that segregation distortion, of schizophrenia susceptibility genes, may be a possible causative factor in the high incidence of schizophrenia.Molecular Psychiatry (2000) 5, 85-90.
|
10673773 |
2000 |
Sciatic Neuropathy
|
0.200 |
Biomarker
|
disease |
RGD |
Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve.
|
18667152 |
2008 |