Thyroid Neoplasm
|
0.350 |
Biomarker
|
disease |
CTD_human |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
Thyroid Neoplasm
|
0.350 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
Thyroid Neoplasm
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
These findings identify SRC as a target of RAP1GAP depletion and suggest that the downregulation of RAP1GAP in thyroid tumors enhances SRC-dependent signals that regulate cellular architecture and motility.
|
22696507 |
2012 |
Thyroid Neoplasm
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analyzed 197 thyroid tumor samples and showed that Rap1GAP was frequently lost or downregulated in various types of tumors, particularly in the most invasive and aggressive forms of thyroid cancer.
|
20124489 |
2010 |
Thyroid Neoplasm
|
0.350 |
Biomarker
|
disease |
BEFREE |
The more frequent and greater down-regulation of Rap1GAP in PTCs compared with adenomas suggests a role for Rap1GAP depletion in the progression of human thyroid tumors, possibly through unrestrained Rap activity.
|
19066305 |
2009 |
Thyroid Neoplasm
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In support of that notion, Rap1GAP was highly expressed in normal human thyroid cells and downregulated in primary thyroid tumors.
|
17646383 |
2007 |
melanoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Genes deregulated at the DNA and mRNA level included well-known cancer genes partly already linked to melanoma (RAS genes, PTEN, AURKA, MAPK inhibitors Sprouty/Spred), but also novel candidates like SIPA1 (a Rap1GAP).
|
22535842 |
2012 |
melanoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
melanoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, miR-31 overexpression resulted in down-regulation of EZH2 and a de-repression of its target gene rap1GAP; increased expression of EZH2 was associated with melanoma progression and overall patient survival.
|
22948084 |
2012 |
melanoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
Thyroid carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
Thyroid carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
Thyroid carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells.
|
22696507 |
2012 |
Thyroid carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Although activating mutations in Rap have not been described, downregulation of Rap1GAP is frequent in human tumors including thyroid carcinomas.
|
21367844 |
2011 |
Thyroid carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analyzed 197 thyroid tumor samples and showed that Rap1GAP was frequently lost or downregulated in various types of tumors, particularly in the most invasive and aggressive forms of thyroid cancer.
|
20124489 |
2010 |
melanoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Taken together, our findings indicate that down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration.
|
19147557 |
2009 |
melanoma
|
0.340 |
AlteredExpression
|
disease |
LHGDN |
Taken together, our findings indicate that down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration.
|
19147557 |
2009 |
melanoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
In addition, overexpression of Rap1GAP also inhibits focal adhesion formation and decreases melanoma cell migration.
|
19147557 |
2009 |
Malignant neoplasm of pancreas
|
0.330 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
Malignant neoplasm of pancreas
|
0.330 |
Biomarker
|
disease |
CTD_human |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
Malignant neoplasm of pancreas
|
0.330 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is a critical tumor suppressor gene that is downregulated in multiple aggressive cancers, such as head and neck squamous cell carcinoma, melanoma and pancreatic cancer.
|
21532618 |
2011 |
Malignant neoplasm of pancreas
|
0.330 |
Biomarker
|
disease |
BEFREE |
Collectively, our data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer.
|
16424023 |
2006 |
Pancreatic Neoplasm
|
0.310 |
Biomarker
|
disease |
CTD_human |
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
|
22614916 |
2012 |
Pancreatic Neoplasm
|
0.310 |
Biomarker
|
disease |
LHGDN |
Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer.
|
16424023 |
2006 |
Acute Promyelocytic Leukemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
|
22614916 |
2012 |