RAP1GAP, RAP1 GTPase activating protein, 5909

N. diseases: 63; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.350 Biomarker disease CTD_human Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.350 Biomarker disease BEFREE Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.350 AlteredExpression disease BEFREE These findings identify SRC as a target of RAP1GAP depletion and suggest that the downregulation of RAP1GAP in thyroid tumors enhances SRC-dependent signals that regulate cellular architecture and motility. 22696507 2012
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.350 AlteredExpression disease BEFREE In this study, we analyzed 197 thyroid tumor samples and showed that Rap1GAP was frequently lost or downregulated in various types of tumors, particularly in the most invasive and aggressive forms of thyroid cancer. 20124489 2010
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.350 Biomarker disease BEFREE The more frequent and greater down-regulation of Rap1GAP in PTCs compared with adenomas suggests a role for Rap1GAP depletion in the progression of human thyroid tumors, possibly through unrestrained Rap activity. 19066305 2009
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.350 AlteredExpression disease BEFREE In support of that notion, Rap1GAP was highly expressed in normal human thyroid cells and downregulated in primary thyroid tumors. 17646383 2007
CUI: C0025202
Disease: melanoma
melanoma
0.340 Biomarker disease BEFREE Genes deregulated at the DNA and mRNA level included well-known cancer genes partly already linked to melanoma (RAS genes, PTEN, AURKA, MAPK inhibitors Sprouty/Spred), but also novel candidates like SIPA1 (a Rap1GAP). 22535842 2012
CUI: C0025202
Disease: melanoma
melanoma
0.340 Biomarker disease CTD_human Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0025202
Disease: melanoma
melanoma
0.340 AlteredExpression disease BEFREE Furthermore, miR-31 overexpression resulted in down-regulation of EZH2 and a de-repression of its target gene rap1GAP; increased expression of EZH2 was associated with melanoma progression and overall patient survival. 22948084 2012
CUI: C0025202
Disease: melanoma
melanoma
0.340 Biomarker disease BEFREE Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.340 Biomarker disease CTD_human Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.340 Biomarker disease BEFREE Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.340 Biomarker disease BEFREE RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells. 22696507 2012
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.340 AlteredExpression disease BEFREE Although activating mutations in Rap have not been described, downregulation of Rap1GAP is frequent in human tumors including thyroid carcinomas. 21367844 2011
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.340 AlteredExpression disease BEFREE In this study, we analyzed 197 thyroid tumor samples and showed that Rap1GAP was frequently lost or downregulated in various types of tumors, particularly in the most invasive and aggressive forms of thyroid cancer. 20124489 2010
CUI: C0025202
Disease: melanoma
melanoma
0.340 Biomarker disease CTD_human Taken together, our findings indicate that down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. 19147557 2009
CUI: C0025202
Disease: melanoma
melanoma
0.340 AlteredExpression disease LHGDN Taken together, our findings indicate that down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. 19147557 2009
CUI: C0025202
Disease: melanoma
melanoma
0.340 AlteredExpression disease BEFREE In addition, overexpression of Rap1GAP also inhibits focal adhesion formation and decreases melanoma cell migration. 19147557 2009
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.330 Biomarker disease BEFREE Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.330 Biomarker disease CTD_human Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma. 22614916 2012
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.330 Biomarker disease BEFREE Rap1GAP is a critical tumor suppressor gene that is downregulated in multiple aggressive cancers, such as head and neck squamous cell carcinoma, melanoma and pancreatic cancer. 21532618 2011
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.330 Biomarker disease BEFREE Collectively, our data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer. 16424023 2006
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.310 Biomarker disease CTD_human Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro. 22614916 2012
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.310 Biomarker disease LHGDN Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer. 16424023 2006
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.300 Biomarker disease CTD_human Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro. 22614916 2012