|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Mechanically, RAP2B was identified as a direct target gene of miR-147b and RAP2B rescued the suppression of proliferation and invasion reduced by miR-147b in CRC cells.
|
31121595 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In addition, we disclosed the effect of Rap2B knockdown on cell adhesion, proliferation, migration and invasion by using cell attachment assay, CCK-8 assay, cell migration assay and Wound Healing assay, cell invasion assay, respectively.
|
30997639 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of Rap2B inhibited the proliferation, migration, and invasion of cervical cancer cells.
|
28390112 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We propose that XIST is responsible for OS cell proliferation and invasion and that XIST exerts its function through the miR-320b/RAP2B axis.
|
28409547 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data suggest that Rap2B silencing inhibits the proliferation and invasion in HCC cells.
|
28081729 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
More importantly, restoration of RAP2B activity rescued the inhibitory effects of miR-194 on cell proliferation and invasion in J82 cells.
|
27133066 |
2016 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
miR-342-3p targets RAP2B to suppress proliferation and invasion of non-small cell lung cancer cells.
|
25663460 |
2015 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our data indicated that Rap2B expression is significantly increased in human suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, which may provide a new target for the treatment of suprarenal epithelioma.
|
24951956 |
2014 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we show that down-regulation of PLCgamma1 expression severely impairs activation of the small GTP-binding protein Rac and cell invasion in breast cancer cell lines and U87 in vitro.
|
19074886 |
2008 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Small GTP-binding protein, Rho, both increased and decreased cellular motility, activation of matrix metalloproteinase 2 and invasion of human osteosarcoma cells.
|
11346466 |
2001 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells.
|
9478968 |
1998 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
In addition, our tumorigenesis assay showed that Rap2B knockdown suppressed cervical cancer cell growth and metastasis in vivo.
|
28390112 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
As a confirmed target gene of p53, we believe that further investigating potential functions of Rap2B in autophagy and tumorigenesis will provide a novel strategy for cancer therapy.
|
29029384 |
2017 |
|
Carcinogenesis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Previous studies have shown that Rap2B aberrantly expressed in human carcinogenesis and promoted the development of tumors via multiple signaling pathways.
|
28691643 |
2017 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Increasing focus on Ras signaling pathway reveals critical effects of Rap2B on tumorigenesis.
|
27012552 |
2016 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Rap2B gene may play an important role in the process of lung cancer and global DNA hypomethylation might be an early event in tumorigenesis.
|
26308105 |
2015 |
|
Carcinogenesis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Ras homolog-enriched in brain (Rheb), a small GTP-binding protein, is associated with prostate carcinogenesis through activating mammalian target of rapamycin (mTOR) signaling pathway.
|
20127734 |
2010 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Rap2B, a member of the GTP-binding proteins, is generally up-regulated in numerous types of tumors.
|
30997639 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Rap2B, belonging to the Ras superfamily, has been implicated in cancer development and functions as a tumor promoter.
|
28390112 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The small GTP-binding protein Rab25 is associated with tumor formation and progression.
|
29371698 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Rap2B silencing obviously inhibited the proliferation, migration, and invasion of HCC cells, as well as attenuated xenografted tumor growth in vivo.
|
28081729 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
However, the function of Rap2B in tumor angiogenesis that is necessary for tumor growth and metastasis remains unknown.
|
28691643 |
2017 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In addition, our tumorigenesis assay showed that Rap2B knockdown suppressed cervical cancer cell growth and metastasis in vivo.
|
28390112 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
However, the function of Rap2B in tumor angiogenesis that is necessary for tumor growth and metastasis remains unknown.
|
28691643 |
2017 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The small GTP-binding protein Arf6 is known to be an important regulator of the actin cytoskeleton and of cell motility associated with metastasis.
|
19948141 |
2009 |