Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
ATRA-induced Pin1 ablation degrades the protein encoded by the fusion oncogene PML-RARA and treats APL in APL cell and animal models as well as in human patients.
|
25849135 |
2015 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
<i>TBL1XR1-RARB</i> as an oncogenic protein exerts effects similar to those of <i>PML-RARA</i>, underpinning the importance of retinoic acid pathway alterations in the pathogenesis of APL.<b>Significance:</b> These findings report a novel and distinct genetic subtype of acute promyelocytic leukemia (APL) by illustrating that the majority of APL without RARA translocations harbor RARB translocations.<i></i>.
|
29921692 |
2018 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia zinc finger (PLZF), originally identified as a fusion with retinoic acid receptor alpha in rare cases of all-trans-retinoic acid-resistant acute promyelocytic leukemia, is a transcriptional repressor that recruits histone deacetylase-containing corepressor complexes to specific DNA binding sites.
|
15964811 |
2005 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The MLF1 and RARA genes are fused with NPM1 in myelodysplastic syndrome and acute myeloid leukemia (AML) with t(3;5) and acute promyelocytic leukemia with t(5;17), respectively.
|
16984370 |
2006 |
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that PML/RARA-mediated downregulation of <i>Irf8</i> transcript levels contributes to the initiation of APL.
|
30266821 |
2018 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human acute promyelocytic leukemia (APL) is characterized by a specific balanced translocation t(15;17)(q22;q21) involving the PML and RARA genes.
|
26053431 |
2015 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The literature review indicated that allogeneic hematopoietic stem cell transplantation might be a therapeutic method to treat APL with IRF2BP2-RARA fusion.
|
31447564 |
2019 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cryptic insertion of PML-RARA into the 3p25 locus in an acute promyelocytic leukemia with t(3;17)(p25;q21).
|
20633765 |
2010 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia.
|
11929790 |
2002 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is associated with rearrangement of the retinoic acid receptor alpha (RARalpha) gene leading to the formation of chimeric receptor proteins.
|
16473273 |
2006 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the RAR-alpha gene is directly involved in the t(15;17) translocation in APL and may transcribe aberrant messages.
|
1849600 |
1991 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An extremely restricted region (ERR) of 50 bp within RARA gene intron 2 was identified as the cluster region of breakpoints by polymerase chain reaction and sequence analysis of DNA from APL patients.
|
8208541 |
1994 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this chapter we explore the biology of the RARalpha, the fusion proteins created in APL and the normal forms of the partner proteins.
|
12935958 |
2003 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this article we laid emphasis on the rearrangement of the RARα gene and its different fusion partners resulting in variant forms of APL, their implication in underlying molecular pathogenesis of APL and also the different diagnostic modalities that should be employed for their rapid and accurate diagnosis.
|
29700805 |
2019 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Selective targeting of the PML/RARα oncoprotein demonstrates a successful molecular targeted therapy in acute promyelocytic leukemia (APL) with a typical t(15:17) chromosomal translocation.
|
27732960 |
2016 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our data are strong evidence that the retinoic acid receptor alpha gene plays a crucial role in the leukemogenesis of APL.
|
1848017 |
1991 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyelocytic leukemia (APL) patients.
|
16501610 |
2006 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that the frequency of RARA-PML expression has been underestimated and highlights remarkable complexity at chromosomal breakpoint regions in APL even in cases with an apparently simple balanced t(15;17)(q24;q12).
|
20155840 |
2010 |
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Acute promyelocytic leukaemia (APL) driven by chimeric transcription factors encoding retinoic acid receptor alpha fusions is the paradigm of targeted cancer therapy, in which the application of all-trans retinoic acid (ATRA) treatments have markedly transformed this highly fatal cancer to a highly manageable disease.
|
25247321 |
2015 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.
|
2170850 |
1990 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic mutations on PML-RARα in acute promyelocytic leukemia (APL) are reported to associate with arsenic trioxide (ATO) or all-trans retinoic acid (ATRA) resistance.
|
30824184 |
2019 |
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
From a retinoic acid (RA)-sensitive acute promyelocytic leukemia (APL) cell line, we derived an RA-resistant clone characterized by a block in transcription initiation, despite maintaining wild-type PML/RARA expression.
|
26997274 |
2016 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Besides PML-RAR, two endogenous RARα proteins are present in APL blasts, i.e.RARα1 and RARα2.
|
27419624 |
2017 |
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by a t(15;17) chromosomal translocation with breakpoints within the retinoic acid alpha receptor (RAR alpha) gene on 17 and the PML gene, which encodes a putative transcription factor, on 15.
|
7529139 |
1995 |
Acute Promyelocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
BRD4 interacts with PML/RARα in acute promyelocytic leukemia.
|
30552662 |
2018 |