|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The MLF1 and RARA genes are fused with NPM1 in myelodysplastic syndrome and acute myeloid leukemia (AML) with t(3;5) and acute promyelocytic leukemia with t(5;17), respectively.
|
16984370 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human acute promyelocytic leukemia (APL) is characterized by a specific balanced translocation t(15;17)(q22;q21) involving the PML and RARA genes.
|
26053431 |
2015 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The literature review indicated that allogeneic hematopoietic stem cell transplantation might be a therapeutic method to treat APL with IRF2BP2-RARA fusion.
|
31447564 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cryptic insertion of PML-RARA into the 3p25 locus in an acute promyelocytic leukemia with t(3;17)(p25;q21).
|
20633765 |
2010 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is associated with rearrangement of the retinoic acid receptor alpha (RARalpha) gene leading to the formation of chimeric receptor proteins.
|
16473273 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the RAR-alpha gene is directly involved in the t(15;17) translocation in APL and may transcribe aberrant messages.
|
1849600 |
1991 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An extremely restricted region (ERR) of 50 bp within RARA gene intron 2 was identified as the cluster region of breakpoints by polymerase chain reaction and sequence analysis of DNA from APL patients.
|
8208541 |
1994 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this article we laid emphasis on the rearrangement of the RARα gene and its different fusion partners resulting in variant forms of APL, their implication in underlying molecular pathogenesis of APL and also the different diagnostic modalities that should be employed for their rapid and accurate diagnosis.
|
29700805 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that the frequency of RARA-PML expression has been underestimated and highlights remarkable complexity at chromosomal breakpoint regions in APL even in cases with an apparently simple balanced t(15;17)(q24;q12).
|
20155840 |
2010 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.
|
2170850 |
1990 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic mutations on PML-RARα in acute promyelocytic leukemia (APL) are reported to associate with arsenic trioxide (ATO) or all-trans retinoic acid (ATRA) resistance.
|
30824184 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by a t(15;17) chromosomal translocation with breakpoints within the retinoic acid alpha receptor (RAR alpha) gene on 17 and the PML gene, which encodes a putative transcription factor, on 15.
|
7529139 |
1995 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A new morphologic classification system for acute promyelocytic leukemia distinguishes cases with underlying PLZF/RARA gene rearrangements.
|
10942370 |
2000 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by the t(15;17) chromosomal translocation, which results in fusion of the retinoic acid receptor alpha (RARA) gene to another gene, most commonly promyelocytic leukemia (PML).
|
19451695 |
2009 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This phenotype is induced by specific acute myeloid leukemia-associated translocations, such as t(15;17) and t(11;17), which involve an identical portion of the retinoic acid receptor alpha (RARalpha) and either the promyelocytic leukemia (PML) or promyelocytic zinc finger (PLZF) genes, respectively.
|
16024608 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
While most cases of APL harboring the PML/RARA fusion respond to all-trans retinoic acid (ATRA), some variant RARA rearrangements are ATRA insensitive.
|
31447065 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Testing of 163 newly diagnosed patients (including 46 APL cases) with the PML-RARA immunobead assay showed full concordance with the PML-RARA PCR results.
|
22948489 |
2012 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor alpha (RARa) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes.
|
17217040 |
2007 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
APL is characterized cytogenetically by a t(15;17) translocation which involves both the PML gene on chromosome 15 and the RARa gene on chromosome 17 and gives rise to the PML/RARa fusion protein.
|
7825969 |
1995 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate that FOXC1 is consistently repressed in APL due to hypermethylation and the presence of the PML-RARA rearrangement.
|
29137406 |
2017 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is thought to be caused by the t(15,17) translocation that fuses the PML gene to that of the retinoic acid receptor alpha (RAR alpha) and generates a PML/RAR alpha fusion protein.
|
8400236 |
1993 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The characteristic reciprocal translocation t(15;17) of acute promyelocytic leukemia (APL) disrupts the PML gene on chromosome 15 and the retinoic acid receptor-alpha (RAR-alpha) gene on chromosome 17.
|
8400225 |
1993 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by a chromosomal t(15;17) translocation that fuses the gene encoding the promyelocytic leukemia protein (PML) to that encoding retinoic acid receptor alpha (RARA).
|
20724820 |
2010 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We next analysed gene expression profiles of our identified target genes in PLZF/RARA APL patients and analysed DNA sequences and epigenetic modification at PLZF/RARA binding sites.
|
21949697 |
2011 |
|
Acute Promyelocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A PML/RARA chimeric gene on chromosome 12 in a patient with acute promyelocytic leukemia (M4) associated with a new variant translocation: t(12;15;17)(q24;q24;q11).
|
23292868 |
2013 |