|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The consistent identification by RT-PCR of the fusion of the PML and RAR alpha genes in AML3 patients suggest that this method will provide a useful tool for the diagnosis and detection of minimal residual disease in these patients.
|
1375840 |
1992 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further molecular analysis of this patient showed a rearrangement between the RAR alpha gene and a newly discovered zinc finger gene named PLZF (promyelocytic leukemia zinc finger).
|
8387545 |
1993 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This translocation involves the retinoic acid receptor-alpha (RAR-alpha) on chromosome 17 and the promyelocytic leukemia locus (PML) on chromosome 15 and results in the transcription of novel fusion messenger RNAs.
|
8238249 |
1993 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
At diagnosis, 13 pts had promyelocytic leukemia (PML) retinoic acid receptor-alpha (RAR-alpha)-rearranged acute promyelocytic leukemia (APL), 8 Philadelphia positive (Ph'+) break-point cluster region (BCR+) chronic myeloid leukemia (CML), and 3 Ph'+ (BCR+) acute lymphoblastic leukemia (ALL).
|
8392400 |
1993 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a patient with acute promyelocytic leukemia, the limits of leukemic cell detection by RT-PCR using either WT1 or promyelocytic leukemia/retinoic acid receptor-alpha gene primers were 10(-3) to 10(-4) and 10(-4) for bone marrow, and 10(-5) and 10(-4) for peripheral blood, respectively.
|
7949179 |
1994 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To test the efficacy of fluorescence in situ hybridization (FISH) for detection of fusion of the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) genes in patients with treated or untreated acute promyelocytic leukemia (APL).
|
7967757 |
1994 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein.
|
8622986 |
1996 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis for the promyelocytic leukemia-retinoic acid receptor alpha (PML-RAR alpha) hybrid gene at diagnosis was performed in 16 patients by means of reverse transcription-polymerase chain reaction (RT-PCR) analysis, and all were RT-PCR+ for the hybrid gene.
|
8695858 |
1996 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The bcr1- and bcr3- promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR alpha) are the two major fusion proteins expressed in acute promyelocytic leukemia (APL) patients.
|
9242550 |
1997 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To examine, in newly diagnosed patients with acute promyelocytic leukemia (APL), the prognostic significance of secondary cytogenetic changes and the relationship between such changes and the two major promyelocytic leukemia-retinoic acid receptor alpha (PML-RAR alpha) mRNA types.
|
9164186 |
1997 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by a reciprocal 15; 17 chromosomal translocation, which fuses the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARalpha) genes, leading to the expression of the PML/RARalpha fusion oncoprotein.
|
9354674 |
1997 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Bone marrow and blood became negative in fluorescense in situ hybridization analysis and semi-quantitative polymerase chain reaction showed a profound reduction of promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion transcripts.
|
10381496 |
1999 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Bone marrow examination revealed the presence of atypical promyelocytes with Auer rods; cytogenetics showed t(15;17), and molecular analysis detected promyelocytic leukemia-retinoic acid receptor alpha rearrangement.
|
10203104 |
1999 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RA-induced expression of C/EBPepsilon markedly increased in U937 myelomonoblasts that were induced to express promyelocytic leukemia/RARalpha (PML/RARalpha), but not in those induced to express promyelocytic leukemia zinc finger/RARalpha (PLZF/RARalpha).
|
10330422 |
1999 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is characterized by a block to myeloid differentiation caused by expression of the fusion oncoprotein promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha).
|
10766166 |
2000 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(11;17)(q21;q23)-associated acute promyelocytic leukemia creates the promyelocytic leukemia zinc finger PLZFt/RAR alpha fusion protein and, in a similar manner, inhibits RAR alpha target gene expression and myeloid differentiation.
|
11090081 |
2000 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Such specific targeting of the viral oncoprotein by As-IFN treatment, reminiscent of As targeting of promyelocytic leukemia/retinoic acid receptor-alpha in acute promyelocytic leukemia, provides strong rational for combined As-IFN therapy in ATL patients.(Blood.2000;96:2849-2855)
|
11023521 |
2000 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The t(15;17) translocation, found in 95% of acute promyelocytic leukemia, encodes a promyelocytic leukemia (PML)-retinoic acid receptor alpha (RARalpha) fusion protein.
|
11301322 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
No significant differences were found with regard to mean WBC count and promyelocytic leukemia/retinoic acid receptor-alpha junction type in comparisons of patients with EMD and hematologic relapse.
|
11600603 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we review how a detailed analysis of the functions of two of these RARalpha partners, the promyelocytic leukemia (PML) and promyelocytic leukemia zinc finger (PLZF) proteins, has allowed a greater understanding of the molecular mechanisms implicated in APL pathogenesis.
|
11561158 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid.
|
11454693 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One form of APL is associated with the translocation t(11;17), which joins the promyelocytic leukemia zinc finger (PLZF) and retinoic acid receptor alpha (RARalpha) genes.
|
11719366 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several patients in CR became polymerase chain reaction (PCR) negative for promyelocytic leukemia/retinoic acid receptor-alpha (PML/RARalpha) after liposomal ATRA alone.
|
11133744 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A few years later, excitement with APL was further enhanced by the discovery that a cytogenetic marker for this disease, the t(15:17) reciprocal chromosomal translocation, involves a fusion between the retinoic acid receptor alpha (RARalpha) gene and a previously unknown locus named promyelocytic leukemia (PML).
|
11704847 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
After the introduction of ATRA, in addition to clinical features such as hyperleukocytosis (white blood cell count > 10 x 10(9)/L) or thrombocytopenia (platelet count < 10 x 10(3)/L) at presentation, immunophenotype markers and polymerase chain reaction status for promyelocytic leukemia/retinoic acid receptor-alpha during follow-up also had an impact on prognosis.
|
11172535 |
2001 |