|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Chemerin, a chemoattractant protein, acts <i>via</i> a G-protein coupled chemokine receptor, <i>i.e.</i> Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM).
|
29682177 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
This finding together with the positive association of chemerin and leptin with markers of insulin resistance, suggests that these adipokines and more especially chemerin and leptin accompanied by their adipose tissue expression could contribute to the increased insulin resistance and low grade inflammation that characterizes GDM-obese women.
|
29337272 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Local effects of chemerin from fat may explain this discrepancy and support chemerin's association with hypertension and obesity.
|
29467310 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Ovarian chemerin was upregulated by 5α-dihydrotestosterone (DHT) in lean and overweight rats; while increased serum chemerin levels were only evident in overweight rats, suggesting that the serum chemerin may be reflective of a systemic response and associated with obesity, whereas increased ovarian chemerin expression is a localized response independent of the metabolic status.
|
29688269 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Together, the exciting findings gathered in the last decade clearly indicate a crucial multifaceted role for chemerin in the regulation of energy balance, making it a promising candidate for urgently needed pharmacological treatment strategies for obesity.
|
29848608 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chemerin, a newly identified adipokine secreted by adipose tissue, is known to be associated with obesity, metabolic syndrome, and insulin resistance.
|
30598628 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this review article, we aim to evaluate the current literature in understanding the role of Chemerin in vascular health and furthermore, its role in maintaining vascular homeostasis with respect to inflammation, obesity and associated Metabolic Syndrome (MetS) risk factors.
|
30016719 |
2018 |
|
Granulosa Cell Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Bisphenol A and its derivatives decrease expression of chemerin, which reverses its stimulatory action in ovarian cancer cells.
|
29653259 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
However, the relationship between visceral adiposity and chemerin levels remains unclear in subjects with T2DM.
|
28120562 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Chemokine like receptor- 1 (CMKLR-1) receptor that regulates chemerin levels exhibits a potential therapeutic target for insulin resistance, type 2 diabetes and cancer treatment.
|
28625137 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overweight/obese adolescents had significantly higher mean nocturnal serum chemerin area under the curve (AUC) levels (348.2±133.3 vs. 241.7±67.7 vs. ng/mL×h, p<0.001) compared to normal-weight controls.
|
27941174 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-<i>γ</i> Coativator-1 Genes and the Risk for Obesity.
|
28947843 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to quantify two molecules (ghrelin and chemerin), released in association with food intake and obesity, in periodontally healthy and diseased individuals with respect to different body mass categories.
|
28631313 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A high level of chemerin in humans is considered as a marker of inflammation in insulin resistance and obesity as well as in type 2 diabetes mellitus.
|
28625137 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, serum chemerin levels were associated significantly with obesity, especially visceral adipose tissue, in subjects with T2DM.
|
28120562 |
2017 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Elevated levels of chemerin have been found in individuals with obesity, type 2 diabetes, and osteoporosis.
|
28029186 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Chemerin levels were higher in patients with Type 2 diabetes mellitus (T2DM, n=111) and the metabolic syndrome (MetS, n=147) than in subjects without T2DM (191.5±72.9 vs. 169.7±64.7ng/ml, p=0.001) or the MetS (201.2±71.0 vs. 163,1ng/ml, p<0.001), but did not differ significantly between patients with significant CAD (n=247) and those without significant CAD (177.1±67.0 vs. 171.7±67.2ng/ml, p=0.193).
|
26304698 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study suggested that a role of STRA6 polymorphism could also be of value in predicting the risk of T2DM while RARRES2 polymorphism could not predict the risk of T2DM.
|
27446956 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chemerin is an adipokine proposed to link obesity and chronic inflammation of adipose tissue.
|
25521368 |
2014 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Obesity increased serum chemerin and lipocalin-2 levels and tended to decrease omentin-1, irrespective of PCOS.
|
23337724 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chemerin is an adipocyte-secreted hormone and has recently been associated with obesity and the metabolic syndrome.
|
23904282 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
To elucidate whether the increased circulating chemerin concentrations in obese subjects are associated with the increase of fat mass, the increase in chemerin gene expression in adipose tissue or both.
|
23211604 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chemerin is an adipokine involved in obesity, inflammation, and innate immune system that is highly expressed in the liver.
|
23507574 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Herein we summarize the state of the art of two novel adipokines and their impaired or protective action in obesity: chemerin and vaspin.
|
23281340 |
2013 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The expression of hepatic chemerin and CMKLR1 was correlated with the measures of obesity (P<0.05).
|
23935128 |
2013 |