Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.060 GeneticVariation group BEFREE Excessive innate immune response is harmful to the host, and aberrant activation of the cytoplasmic viral RNA sensors RIG-I and MDA5 leads to autoimmune disorders. 31433974 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.060 GeneticVariation group BEFREE Mutations in RIG-I (C268F and E373A) lead to impaired ATPase activity, thereby driving hyperactive signaling associated with autoimmune diseases. 30560918 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.060 Biomarker group BEFREE LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways. 29525183 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.060 Biomarker group BEFREE It has been suggested that RIG-I has a ‘proof-reading’ mechanism for rejecting host RNA targets, and that disruptions of this selectivity filter give rise to autoimmune diseases. 28180316 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.060 Biomarker group BEFREE Here, we hypothesized that altered expression or function of MAVS, a key molecule downstream of the viral sensors RIG-I and MDA-5, may impair antiviral cell signalling and thereby influence the risk for systemic lupus erythematosus (SLE), the prototype autoimmune disease. 21268286 2011
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.060 Biomarker group BEFREE These results provide new insights into the structure-function relationship of RIG-I-like receptors as well as into human RIG-I-like receptor polymorphisms, antiviral innate immunity, and autoimmune diseases. 19324880 2009