Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 Biomarker disease BEFREE Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to testify the theory of superposition of traditional Chinese Medicine efficacy. 31051218 2019
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 Biomarker disease BEFREE RSV NS1 and NS2 have been shown to interfere with RIG-I-mediated antiviral signaling. 30558248 2018
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 Biomarker disease BEFREE Inhibition of BRD4 blocks Toll-like receptor 3 (TLR3)-dependent neutrophilia and RSV-induced inflammation, demonstrating its importance in the mucosal innate response <i>in vivo</i> Our study shows that BRD4 plays a central role in inflammation and activation of the IRF7-RIG-I amplification loop vital for mucosal interferon expression. 28077651 2017
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 AlteredExpression disease BEFREE Western blot analyses further revealed that 4(3H)-Quinazolone inhibited RSV-induced expression of RIG-I (Retinoic acid-Inducible Gene-I) in mouse macrophages dose-dependently, thereby suppressing the transcription of IFN-β, with lower effects than those of ribavirin. 28957692 2017
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 Biomarker disease BEFREE The host antiviral response to RSV acts via retinoic acid-inducible gene I (RIG-I). 25972545 2015
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 Biomarker disease BEFREE Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. 24391215 2014
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 Biomarker disease BEFREE Here, we performed a thorough analysis of the temporal involvement of RIG-I and MDA5 in the regulation of IRF-3 during respiratory syncytial virus (RSV) infection. 24800889 2014
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 AlteredExpression disease BEFREE Stimulation with RSV or Poly(I:C) induced IFN-β expression, which resulted in an increased expression of the viral receptors TLR3 and RIG-I, as well as an increased NOD2 expression. 22730064 2012
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.090 AlteredExpression disease BEFREE A significant positive correlation was observed only between RSV viral load and RIG-1 mRNA levels. 19386802 2009