PLAAT4, phospholipase A and acyltransferase 4, 5920
N. diseases: 190; N. variants: 1
Source: ALL
Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
---|---|---|---|---|---|---|---|
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0.090 | Biomarker | disease | BEFREE | Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to testify the theory of superposition of traditional Chinese Medicine efficacy. | 31051218 | 2019 |
|
0.090 | Biomarker | disease | BEFREE | RSV NS1 and NS2 have been shown to interfere with RIG-I-mediated antiviral signaling. | 30558248 | 2018 |
|
0.090 | Biomarker | disease | BEFREE | Inhibition of BRD4 blocks Toll-like receptor 3 (TLR3)-dependent neutrophilia and RSV-induced inflammation, demonstrating its importance in the mucosal innate response <i>in vivo</i> Our study shows that BRD4 plays a central role in inflammation and activation of the IRF7-RIG-I amplification loop vital for mucosal interferon expression. | 28077651 | 2017 |
|
0.090 | AlteredExpression | disease | BEFREE | Western blot analyses further revealed that 4(3H)-Quinazolone inhibited RSV-induced expression of RIG-I (Retinoic acid-Inducible Gene-I) in mouse macrophages dose-dependently, thereby suppressing the transcription of IFN-β, with lower effects than those of ribavirin. | 28957692 | 2017 |
|
0.090 | Biomarker | disease | BEFREE | The host antiviral response to RSV acts via retinoic acid-inducible gene I (RIG-I). | 25972545 | 2015 |
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0.090 | Biomarker | disease | BEFREE | Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. | 24391215 | 2014 |
|
0.090 | Biomarker | disease | BEFREE | Here, we performed a thorough analysis of the temporal involvement of RIG-I and MDA5 in the regulation of IRF-3 during respiratory syncytial virus (RSV) infection. | 24800889 | 2014 |
|
0.090 | AlteredExpression | disease | BEFREE | Stimulation with RSV or Poly(I:C) induced IFN-β expression, which resulted in an increased expression of the viral receptors TLR3 and RIG-I, as well as an increased NOD2 expression. | 22730064 | 2012 |
|
0.090 | AlteredExpression | disease | BEFREE | A significant positive correlation was observed only between RSV viral load and RIG-1 mRNA levels. | 19386802 | 2009 |