|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nonetheless, the physiological viral ligands activating RIG-I during IAV infection remain underexplored.
|
30602605 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Innate immune sensing of influenza A virus (IAV) requires retinoic acid-inducible gene I (RIG-I), a fundamental cytoplasmic RNA sensor.
|
30760567 |
2019 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG-I expression in lung epithelial cells.
|
28892164 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data further suggest that NS1 also posttranscriptionally alters RIG-I pre-mRNA processing by binding to the RIG-I pre-mRNA.<b>IMPORTANCE</b> A key virulence factor of influenza A virus is the NS1 protein, which inhibits various cellular processes to facilitate viral gene expression.
|
30258002 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Retinoic acid inducible gene-I (RIG-I) is a cytoplasmic RNA sensor for detecting a variety of RNA viruses including influenza A viruses.
|
30286408 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The nuclear RIG-I, along with its cytoplasmic counterpart, senses influenza A virus (IAV) nuclear replication leading to a cooperative induction of type I interferon response.
|
30097581 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, the results indicated that although RIG-I is important in innate cytokine responses <i>in vitro</i>, individual deletion of the genes encoding RIG-I or MAVS did not change survival or innate responses <i>in vivo</i> after IAV infection in mice.
|
30532653 |
2018 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that IAV infection led to low body weight and high viral load and high expression of RIG-I, IRF3, IRF7, and NF-<i>κ</i>B mRNA, as well as RIG-I and NF-<i>κ</i>B p65 protein.
|
29681974 |
2018 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, RIG-I-knockout 293T cells were used to package the IFN-sensitive influenza A/WSN/33 (H1N1) virus expressing the mutant NS1 R38A/K41A.
|
29765910 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We recently found that the bent duplex RNA from the influenza A panhandle promoter activates RIG-I even in the absence of a 5'-triphosphate moiety.
|
29373735 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
RIG-I overexpression restored the innate immune response in CS-exposed mice to that seen in sham-exposed WT mice during IAV infection, and is likely responsible for enhanced survival in RIG-I TG mice as restoration preceded death of the animals.
|
28865477 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I.
|
27376632 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate in an Mx1-expressing mouse model of influenza A virus infection that a single intravenous injection of low-dose RIG-I ligand 5'-triphosphate RNA (3pRNA) completely protected mice from a lethal challenge with influenza A virus for at least 7 days.
|
28760668 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza A virus (IAV) can be recognized by retinoic acid-inducible gene I (RIG-I) to activate the type I interferon response and induce antiviral effects.
|
28955326 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We will highlight three major functions of RIG-I against FLUAV: IFN induction, signaling-independent direct antiviral activity, and assembly of an inflammasome.
|
27318973 |
2016 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated retinoic acid-inducible protein I (RIG-I) and interferon (IFN) induction by influenza A virus (IAV) in human bronchial epithelial cells (HBEC) isolated from smokers or nonsmokers.
|
27604339 |
2016 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is known that the influenza A virus NS1 protein (NS1-A) interacts with RIG-I and TRIM25 to suppress the activation of RIG-I-mediated signaling.
|
27122586 |
2016 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, Duox2-derived ROS are necessary for the innate immune response and trigger the induction of RIG-I and MDA5 to resist IAV infection in human nasal epithelium and mouse nasal mucosa.
|
25751630 |
2015 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I.
|
24942585 |
2014 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, neither RIG-I-like receptors nor MyD88-dependent Toll-like receptors were found to be involved in the activation of JNK upon IAV infection.
|
24872593 |
2014 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
|
23209422 |
2012 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings show that influenza A(H1N1)pdm09 virus suppresses anti-viral immune responses in infected human lung through inhibition of viral-mediated induction of the pattern recognition receptor, RIG-I, though proinflammatory cytokine induction was unaltered.
|
23185463 |
2012 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, expression of the RNA receptors Rig-I and MDA5 was increased upon stimulation with virion extracted vRNA or IAV infection.
|
21899695 |
2011 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we report that the influenza A virus nonstructural protein 1 (NS1) specifically inhibits TRIM25-mediated RIG-I CARD ubiquitination, thereby suppressing RIG-I signal transduction.
|
19454348 |
2009 |