RASA2, RAS p21 protein activator 2, 5922

N. diseases: 116; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma
0.330 AlteredExpression disease BEFREE We have shown that wild type RASA1, but not identified mutants, suppresses soft agar colony formation and tumor growth of BRAF mutated melanoma cell lines via its RasGAP activity toward R-Ras (related RAS viral (r-ras) oncogene homolog) isoform. 26993606 2016
CUI: C0025202
Disease: melanoma
melanoma
0.330 GeneticVariation disease BEFREE Inactivating NF1 mutations were present in 46% of melanomas expressing wild-type BRAF and RAS, occurred in older patients and showed a distinct pattern of co-mutation with other RASopathy genes, particularly RASA2. 26214590 2015
CUI: C0025202
Disease: melanoma
melanoma
0.330 Biomarker disease CTD_human These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer. 26502337 2015
CUI: C0025202
Disease: melanoma
melanoma
0.330 Biomarker disease CTD_human Inactivating NF1 mutations were present in 46% of melanomas expressing wild-type BRAF and RAS, occurred in older patients and showed a distinct pattern of co-mutation with other RASopathy genes, particularly RASA2. 26214590 2015
CUI: C0025202
Disease: melanoma
melanoma
0.330 AlteredExpression disease BEFREE These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer. 26502337 2015