|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
|
19234134 |
2009 |
|
Mammary Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Dephosphorylation of Rb (Thr-821) in response to cell stress.
|
16764854 |
2006 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The data presented here demonstrate that changes to the RB1 gene leading to loss of expression of both alleles are frequent in primary human breast tumours.
|
2543943 |
1989 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These results imply that PRB-enriched breast tumors may respond well to anticancer therapies that include inhibitors of angiogenesis.
|
15026368 |
2004 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer.
|
17160137 |
2007 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer.
|
17671693 |
2007 |
|
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
When combined with a previous study of chromosome 13 with emphasis on BRCA2 and Rb1 genes, this work allowed to distinguish a total of 12 regions of LOH, variably affected in breast tumors and correlated with prognostic parameters.
|
9018120 |
1997 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
The HBP1 transcriptional repressor participates in RAS-induced premature senescence.
|
16966377 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
E2F1 expression is related with the poor survival of lymph node-positive breast cancer patients treated with fluorouracil, doxorubicin and cyclophosphamide.
|
14672398 |
2003 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure.
|
18381962 |
2008 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response.
|
20948315 |
2010 |
|
Mammary Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
PRA and PRB promoters were methylated in 9.6% and 14.1% of the breast tumors, respectively.
|
21459801 |
2011 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node.
|
12096344 |
2002 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The relative expression of PRA and PRB proteins was determined by dual immunofluorescence histochemistry in archival breast tumors and associations with clinical and reproductive history assessed.
|
25917868 |
2015 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Lack of functional pRb results in attenuated recovery of mRNA synthesis and increased apoptosis following UV radiation in human breast cancer cells.
|
12085226 |
2002 |
|
Carcinoma
|
0.370 |
GeneticVariation
|
group |
BEFREE |
In virus-positive tumors, a portion of the viral genome, the large T antigen, may inactivate RB1, and in virus-negative Merkel cell carcinomas truncating mutations in the RB1 gene have been identified.
|
25446844 |
2014 |
|
Carcinoma
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Allelic loss at TP53 seems to arise independently of LOH at the RB1 gene in carcinomas of the uterine corpus in humans.
|
16293976 |
2005 |
|
Carcinoma
|
0.370 |
Biomarker
|
group |
CTD_human |
Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
14522882 |
2003 |
|
Carcinoma
|
0.370 |
GeneticVariation
|
group |
BEFREE |
No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung.
|
1381957 |
1992 |
|
Carcinoma
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Inactivation of pRB by gross structural alterations or point mutations in the RB-1 gene has been described in a variety of human tumors, including retinoblastomas, osteosarcomas, and small cell lung carcinomas.
|
9192669 |
1997 |
|
Carcinoma
|
0.370 |
Biomarker
|
group |
BEFREE |
One-third of bladder carcinomas surveyed also carry altered or absent p105-Rb.
|
2181449 |
1990 |
|
Carcinoma
|
0.370 |
AlteredExpression
|
group |
BEFREE |
Cutaneous neuroendocrine (Merkel cell) carcinoma most often arises de novo in the background of a clonally integrated virus, the Merkel cell polyomavirus, and is notable for positive expression of retinoblastoma 1 (RB1) protein and low expression of p53 compared with the rare Merkel cell polyomavirus-negative Merkel cell carcinomas.
|
26022453 |
2015 |
|
Carcinoma
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Our data therefore suggest that major alterations affecting the RB1 gene are rather infrequent in human gastric carcinomas.
|
7947078 |
1994 |
|
Sarcoma
|
0.350 |
GeneticVariation
|
group |
BEFREE |
No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung.
|
1381957 |
1992 |
|
Sarcoma
|
0.350 |
GeneticVariation
|
group |
BEFREE |
Overall, 10 of 25 high-grade sarcomas had detectable alterations of the Rb-1 gene compared with only 1 of 11 low-grade tumors.
|
1988704 |
1991 |