Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To directly investigate the effects of PR isoform expression on the breast cancer proteome, both in the presence and absence of progestin, PRA and PRB were independently stably expressed in T47DC42 PR-null breast cancer cells using a doxycycline (Dox)-regulated promoter.
|
31809870 |
2020 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To directly investigate the effects of PR isoform expression on the breast cancer proteome, both in the presence and absence of progestin, PRA and PRB were independently stably expressed in T47DC42 PR-null breast cancer cells using a doxycycline (Dox)-regulated promoter.
|
31809870 |
2020 |
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The oncogenic effect of HPV16-E7 relies on its binding to the tumor suppressor pRb protein leading to a dysregulated cell duplication.
|
31806970 |
2019 |
Retinoblastoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The der(X) region harboring the RB1 gene was inactivated in a subset of somatic cells, including the retinal cells, in the patient subject which acted as the first hit in the development of her retinoblastoma.
|
31806026 |
2019 |
Severe intellectual disability
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A female patient with retinoblastoma and severe intellectual disability carrying an X;13 balanced translocation without rearrangement in the RB1 gene: a case report.
|
31806026 |
2019 |
Retinoblastoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Retinoblastoma (RB) is a childhood eye tumor, caused by the RB1 gene mutation.
|
31781967 |
2020 |
Malignant neoplasm of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
EGFR/TP53/RB1-mutant lung cancers are at unique risk of histologic transformation, with 25% presenting with de novo SCLC or eventual small cell transformation.
|
31228622 |
2019 |
Retinoblastoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This study might be an important report on emphazing the mutational status of other genes in patients without RB1 gene mutations and having high risk for developing Rb.
|
31207142 |
2019 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Advanced-stage HCC (BCLC B/C) showed higher frequencies of splicing factor 3b subunit 1 (SF3B1) (P = 0.0003), TP53 (P = 0.0006), and RB Transcriptional Corepressor 1 mutations (P = 0.03).
|
31206197 |
2020 |
Retinoblastoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The retinoblastoma RB1 gene has been identified in the 80s as the first tumor suppressor.
|
31176618 |
2019 |
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The retinoblastoma RB1 gene has been identified in the 80s as the first tumor suppressor.
|
31176618 |
2019 |
Neoplasm Metastasis
|
0.360 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, ectopic expression of miR-200b in the Caki-1 and OSRC-2 cell lines suppresses cell migration and invasion in vitro as well as tumor metastases in vivo.
|
31130475 |
2019 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, ectopic expression of miR-200b in the Caki-1 and OSRC-2 cell lines suppresses cell migration and invasion in vitro as well as tumor metastases in vivo.
|
31130475 |
2019 |
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Interestingly, ectopic expression of miR-200b in the Caki-1 and OSRC-2 cell lines suppresses cell migration and invasion in vitro as well as tumor metastases in vivo.
|
31130475 |
2019 |
ovarian neoplasm
|
0.030 |
Biomarker
|
disease |
BEFREE |
Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.
|
31060523 |
2019 |
Malignant neoplasm of ovary
|
0.030 |
Biomarker
|
disease |
BEFREE |
Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.
|
31060523 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.
|
31060523 |
2019 |
Neoplasm Metastasis
|
0.360 |
AlteredExpression
|
phenotype |
BEFREE |
Additionally, resveratrol treatment inhibited SG-mediated Rbfox2 localization, further inhibiting RB1 protein expression, and inhibited specific Rbfox2 localization to the cytoplasm in melanoma B16-F10 cells, thereby effectively inhibiting metastasis and tumor growth ability.
|
31028247 |
2019 |
Tumor Progression
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
RBP fox-1 homolog 2 (Rbfox2), a component of SGs, binds to retinoblastoma 1 (RB1) mRNA, which is closely related to cancer progression; however, the role of Rbfox2 in cancer progression remains largely unknown.
|
31028247 |
2019 |
Hypoglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
5) the sensitivity for the composite adverse perinatal outcome varied substantially among standards (15% for NICHD to 32% for FMF) given mostly to differences in the FPR, and they subsided when the FPR was set to the same value (10%); 6) the comparison of the AUC revealed a significant improvement for the PRB/NICHD (AUC=0.70) compared to Hadlock (AUC=0.66) and FMF (AUC=0.64) standards for the prediction of perinatal mortality; complementarily, the evaluation of the partial AUC (FPR<10%) revealed that the INTERGROWTH-21 standard had an advantage over the Hadlock standard for NICU admissions and mechanical ventilation (all, p<0.05).
|
31006913 |
2020 |
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the expression and distribution of estrogen receptor (ER)α, ERβ, G-protein-coupled ER-1 (GPER), androgen receptor (AR), progesterone receptor (PR)A, PRB and connective tissue growth factor (CTGF) in the vaginal wall among women who had been treated for cervical cancer with radiotherapy.
|
30957588 |
2019 |
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the expression and distribution of estrogen receptor (ER)α, ERβ, G-protein-coupled ER-1 (GPER), androgen receptor (AR), progesterone receptor (PR)A, PRB and connective tissue growth factor (CTGF) in the vaginal wall among women who had been treated for cervical cancer with radiotherapy.
|
30957588 |
2019 |
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the expression and distribution of estrogen receptor (ER)α, ERβ, G-protein-coupled ER-1 (GPER), androgen receptor (AR), progesterone receptor (PR)A, PRB and connective tissue growth factor (CTGF) in the vaginal wall among women who had been treated for cervical cancer with radiotherapy.
|
30957588 |
2019 |
Precursor B-lymphoblastic lymphoma/leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Herein, we present cytogenetic and molecular analysis of a case of B-ALL in a 16-year-old Caucasian boy with t(3;9) FOXP1-ABL1 rearrangement and concurrent loss of IKZF1, CDKN2A, and RB1 gene loci, meeting WHO criteria for Ph-like ALL.
|
30938769 |
2019 |
Ph-Like Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Herein, we present cytogenetic and molecular analysis of a case of B-ALL in a 16-year-old Caucasian boy with t(3;9) FOXP1-ABL1 rearrangement and concurrent loss of IKZF1, CDKN2A, and RB1 gene loci, meeting WHO criteria for Ph-like ALL.
|
30938769 |
2019 |